Cover Image

Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach

Magnetic resonance imaging (MRI) of the brain combined with voxel-based morphometry (VBM) has revealed structural changes of grey and white matter in a range of neurological and psychiatric disorders. However, the cellular basis of volume changes observed with VBM has remained unclear. We devised an...

Full description

Saved in:
Bibliographic Details
Main Authors: Asan, Livia (Author) , Falfán‐Melgoza, Claudia (Author) , Weber-Fahr, Wolfgang (Author) , Beretta, Carlo Antonio (Author) , Kuner, Thomas (Author) , Knabbe, Johannes (Author)
Format: Article (Journal) Chapter/Article
Language:English
Published: February 25, 2019
In: bioRxiv beta

DOI:10.1101/559765
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1101/559765
Verlag, lizenzpflichtig, Volltext: https://www.biorxiv.org/content/10.1101/559765v1
Get full text
Author Notes:Livia Asan, Claudia Falfan-Melgoza, Wolfgang Weber-Fahr, Carlo Beretta, Thomas Kuner and Johannes Knabbe

MARC

LEADER 00000caa a2200000 c 4500
001 1748097024
003 DE-627
005 20230426072715.0
007 cr uuu---uuuuu
008 210211s2019 xx |||||o 00| ||eng c
024 7 |a 10.1101/559765  |2 doi 
035 |a (DE-627)1748097024 
035 |a (DE-599)KXP1748097024 
035 |a (OCoLC)1341392944 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Asan, Livia  |d 1993-  |e VerfasserIn  |0 (DE-588)1226986676  |0 (DE-627)1748088483  |4 aut 
245 1 0 |a Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach  |c Livia Asan, Claudia Falfan-Melgoza, Wolfgang Weber-Fahr, Carlo Beretta, Thomas Kuner and Johannes Knabbe 
264 1 |c February 25, 2019 
300 |a 35 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 11.02.2021 
520 |a Magnetic resonance imaging (MRI) of the brain combined with voxel-based morphometry (VBM) has revealed structural changes of grey and white matter in a range of neurological and psychiatric disorders. However, the cellular basis of volume changes observed with VBM has remained unclear. We devised an approach to systematically correlate changes in grey matter volume (GMV) with cellular composition. Mice were alternately examined with structural MRI and two-photon <i>in vivo</i> microscopy at three time points, taking advantage of age-dependent changes in brain structure. We chose to image fluorescently labelled cell nuclei, because these can be readily imaged in large tissue volumes and allow inferences on several structural parameters: (1) the physical volume as determined from a subset of nuclei used to generate a geometrically defined space, (2) the number of cells, (3) the nearest neighbour distance measured between all nuclei as an indicator of cell clustering, and (4) the volume of the cell nuclei. Using this approach, we found that physical volume did not significantly correlate with GMV change, whereas mean nuclear volume was inversely correlated. When focusing on layers within the imaging volume, positive correlations of GMV were found with cell number near the cortical surface and nearest neighbour distance in deeper layers. Thus, the novel approach introduced here provided new insights into the factors underlying grey matter volume changes.</p> 
700 1 |a Falfán‐Melgoza, Claudia  |e VerfasserIn  |0 (DE-588)1156045177  |0 (DE-627)1018602879  |0 (DE-576)502002271  |4 aut 
700 1 |a Weber-Fahr, Wolfgang  |d 1968-  |e VerfasserIn  |0 (DE-588)115518291X  |0 (DE-627)1016515316  |0 (DE-576)501454578  |4 aut 
700 1 |a Beretta, Carlo Antonio  |e VerfasserIn  |0 (DE-588)1034706667  |0 (DE-627)746187238  |0 (DE-576)382338898  |4 aut 
700 1 |a Kuner, Thomas  |e VerfasserIn  |0 (DE-588)1074267966  |0 (DE-627)831945397  |0 (DE-576)442234562  |4 aut 
700 1 |a Knabbe, Johannes  |e VerfasserIn  |0 (DE-588)1156044022  |0 (DE-627)1018601619  |0 (DE-576)502001534  |4 aut 
773 0 8 |i Enthalten in  |t bioRxiv beta  |d Cold Spring Harbor : Cold Spring Harbor Laboratory, NY, 2013  |g (2019) Artikel-Nummer 559765, 35 Seiten  |h Online-Ressource  |w (DE-627)783307497  |w (DE-600)2766415-6  |w (DE-576)404299903  |7 nnas  |a Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach 
773 1 8 |g year:2019  |g extent:35  |a Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach 
856 4 0 |u https://doi.org/10.1101/559765  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.biorxiv.org/content/10.1101/559765v1  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210211 
993 |a Article 
994 |a 2019 
998 |g 1156044022  |a Knabbe, Johannes  |m 1156044022:Knabbe, Johannes  |d 910000  |d 910600  |e 910000PK1156044022  |e 910600PK1156044022  |k 0/910000/  |k 1/910000/910600/  |p 6  |y j 
998 |g 1074267966  |a Kuner, Thomas  |m 1074267966:Kuner, Thomas  |d 50000  |d 53100  |e 50000PK1074267966  |e 53100PK1074267966  |k 0/50000/  |k 1/50000/53100/  |p 5 
998 |g 1034706667  |a Beretta, Carlo Antonio  |m 1034706667:Beretta, Carlo Antonio  |d 50000  |d 54600  |e 50000PB1034706667  |e 54600PB1034706667  |k 0/50000/  |k 1/50000/54600/  |p 4 
998 |g 115518291X  |a Weber-Fahr, Wolfgang  |m 115518291X:Weber-Fahr, Wolfgang  |d 60000  |e 60000PW115518291X  |k 0/60000/  |p 3 
998 |g 1226986676  |a Asan, Livia  |m 1226986676:Asan, Livia  |d 50000  |e 50000PA1226986676  |k 0/50000/  |p 1  |x j 
999 |a KXP-PPN1748097024  |e 3851403762 
BIB |a Y 
JSO |a {"name":{"displayForm":["Livia Asan, Claudia Falfan-Melgoza, Wolfgang Weber-Fahr, Carlo Beretta, Thomas Kuner and Johannes Knabbe"]},"recId":"1748097024","id":{"eki":["1748097024"],"doi":["10.1101/559765"]},"title":[{"title_sort":"Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach","title":"Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach"}],"person":[{"role":"aut","family":"Asan","display":"Asan, Livia","roleDisplay":"VerfasserIn","given":"Livia"},{"roleDisplay":"VerfasserIn","given":"Claudia","display":"Falfán‐Melgoza, Claudia","family":"Falfán‐Melgoza","role":"aut"},{"display":"Weber-Fahr, Wolfgang","roleDisplay":"VerfasserIn","given":"Wolfgang","family":"Weber-Fahr","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Beretta, Carlo Antonio","given":"Carlo Antonio","family":"Beretta"},{"role":"aut","family":"Kuner","roleDisplay":"VerfasserIn","display":"Kuner, Thomas","given":"Thomas"},{"family":"Knabbe","roleDisplay":"VerfasserIn","given":"Johannes","display":"Knabbe, Johannes","role":"aut"}],"type":{"media":"Online-Ressource","bibl":"chapter"},"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"February 25, 2019"}],"language":["eng"],"note":["Gesehen am 11.02.2021"],"relHost":[{"origin":[{"publisher":"Cold Spring Harbor Laboratory, NY","dateIssuedDisp":"2013-","publisherPlace":"Cold Spring Harbor","dateIssuedKey":"2013"}],"disp":"Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approachbioRxiv beta","language":["eng"],"note":["Gesehen am 14.04.2014"],"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["2013 -"],"recId":"783307497","id":{"zdb":["2766415-6"],"eki":["783307497"]},"titleAlt":[{"title":"bio archive"}],"title":[{"title_sort":"bioRxiv beta","subtitle":"the preprint server for biology","title":"bioRxiv beta"}],"part":{"year":"2019","text":"(2019) Artikel-Nummer 559765, 35 Seiten","extent":"35"},"type":{"bibl":"edited-book","media":"Online-Ressource"}}],"physDesc":[{"extent":"35 S."}]} 
SRT |a ASANLIVIAFGREYMATTER2520 

Similar Items