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Humoral immune response to autologous blood transfusion in hip surgery: whole blood versus packed red cells and plasma

BACKGROUND AND OBJECTIVES: The immune response to the transfused autologous buffy coat content in whole blood has, to date, not been studied in detail. SUBJECTS AND METHODS: Patients undergoing hip arthroplasty were studied according to whether they received autologous whole blood (WB) (n = 30), aut...

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Bibliographic Details
Main Authors: Tolksdorf, Bernd (Author) , Frietsch, Thomas (Author) , Quintel, Michael (Author) , Kirschfink, Michael (Author) , Becker, P. (Author) , Weiler-Lorentz, Arnulf (Author)
Format: Article (Journal)
Language:English
Published: 2001
In: Vox sanguinis
Year: 2001, Volume: 81, Issue: 3, Pages: 180-186
ISSN:1423-0410
DOI:10.1046/j.1423-0410.2001.00106.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1423-0410.2001.00106.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1423-0410.2001.00106.x
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Author Notes:B. Tolksdorf, T. Frietsch, M. Quintel, M. Kirschfink, P. Becker, A. Lorentz
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Summary:BACKGROUND AND OBJECTIVES: The immune response to the transfused autologous buffy coat content in whole blood has, to date, not been studied in detail. SUBJECTS AND METHODS: Patients undergoing hip arthroplasty were studied according to whether they received autologous whole blood (WB) (n = 30), autologous fresh-frozen plasma and buffy coat-poor red cells (RC) (n = 40), or no transfusion (NT) (n = 27). Plasma levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and complement SC5b-9 were analysed by enzyme-linked immunosorbent assay (ELISA) 7 days after surgery. RESULTS: There were no significant between-group differences regarding the time course of TNF-alpha, IL-6 and complement SC5b-9 plasma level changes, the infection rate, or the length of hospital stay. CONCLUSION: In comparison to the impact of surgery on cytokine and complement levels, the transfusion of autologous buffy coat is not relevant.
Item Description:First published: 28 July 2009
Gesehen am 15.02.2021
Physical Description:Online Resource
ISSN:1423-0410
DOI:10.1046/j.1423-0410.2001.00106.x

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