In vivo accumulation of cyclin A and cellular replication factors in autonomous parvovirus minute virus of mice-associated replication bodies
Autonomous parvovirus minute virus of mice (MVM) DNA replication is strictly dependent on cellular factors expressed during the S phase of the cell cycle. Here we report that MVM DNA replication proceeds in specific nuclear structures termed autonomous parvovirus-associated replication bodies, where...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 1, 2001
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| In: |
Journal of virology
Year: 2001, Jahrgang: 75, Heft: 9, Pages: 4394-4398 |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.75.9.4394-4398.2001 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/JVI.75.9.4394-4398.2001 Verlag, lizenzpflichtig, Volltext: https://jvi.asm.org/content/75/9/4394 
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| Verfasserangaben: | Tarig Bashir, Jean Rommelaere, and Celina Cziepluch |
| Zusammenfassung: | Autonomous parvovirus minute virus of mice (MVM) DNA replication is strictly dependent on cellular factors expressed during the S phase of the cell cycle. Here we report that MVM DNA replication proceeds in specific nuclear structures termed autonomous parvovirus-associated replication bodies, where components of the basic cellular replication machinery accumulate. The presence of DNA polymerases α and δ in these bodies suggests that MVM utilizes partially preformed cellular replication complexes for its replication. The recruitment of cyclin A points to a role for this cell cycle factor in MVM DNA replication beyond its involvement in activating the conversion of virion single-stranded DNA to the duplex replicative form. |
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| Beschreibung: | Gesehen am 15.02.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.75.9.4394-4398.2001 |