Resolution of experimental and tick-borne Borrelia burgdorferi infection in mice by passive, but not active immunization using recombinant OspC
Vaccination with outer surface protein A (OspA) of Borrelia burgdorferi prevents subsequent infection and disease in both laboratory animals and humans with high efficacy. OspA-based immunity, however, does not affect established infection due to the loss of OspA expression in the vertebrate host. W...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1999
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| In: |
European journal of immunology
Year: 1999, Jahrgang: 29, Heft: 3, Pages: 946-957 |
| ISSN: | 1521-4141 |
| DOI: | 0.1002/(SICI)1521-4141(199903)29:03<946::AID-IMMU946>3.0.CO;2-P |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/0.1002/(SICI)1521-4141(199903)29:03<946::AID-IMMU946>3.0.CO;2-P
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| Verfasserangaben: | Weimin Zhong, LiseGern, Thomas Stehle, Crisan Museteanu, Michael Kramer, Reinhard Wallich, and Markus M. Simon |
MARC
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| 245 | 1 | 0 | |a Resolution of experimental and tick-borne Borrelia burgdorferi infection in mice by passive, but not active immunization using recombinant OspC |c Weimin Zhong, LiseGern, Thomas Stehle, Crisan Museteanu, Michael Kramer, Reinhard Wallich, and Markus M. Simon |
| 264 | 1 | |c 1999 | |
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| 500 | |a First published: 28 March 2006 | ||
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| 520 | |a Vaccination with outer surface protein A (OspA) of Borrelia burgdorferi prevents subsequent infection and disease in both laboratory animals and humans with high efficacy. OspA-based immunity, however, does not affect established infection due to the loss of OspA expression in the vertebrate host. We show here that repeated passive transfer of mouse and/or rabbit immune sera to recombinant GST-OspC fusion protein resulted in a dose-dependent resolution (1) of fully established arthritis and carditis as well as infection in needle-challenged C.B-17 SCID and (2) of infection in both experimentally and tick-infected BALB/c mice. Unexpectedly, active immunization of disease-susceptible AKR/N mice with GST-OspC only led to prevention but not resolution of disease and infection, in spite of high serum titers of OspC-specific Ab and the expression of ospC in tissue-derived spirochetes. The data suggest that the efficacy of OspC antibody-mediated immunity depends on the immunological history of the recipient and/or environment-dependent regulation of OspC surface expression by spirochetes in vivo. The results encourage further attempts to develop therapeutic vaccination protocols against Lyme disease. | ||
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Antibodies, Bacterial | |
| 650 | 4 | |a Antigens, Bacterial | |
| 650 | 4 | |a Antigens, Surface | |
| 650 | 4 | |a Bacterial Outer Membrane Proteins | |
| 650 | 4 | |a Bacterial Vaccines | |
| 650 | 4 | |a Borrelia burgdorferi Group | |
| 650 | 4 | |a Disease Models, Animal | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Gene Expression | |
| 650 | 4 | |a Glutathione Transferase | |
| 650 | 4 | |a Immunization, Passive | |
| 650 | 4 | |a Kinetics | |
| 650 | 4 | |a Lipoproteins | |
| 650 | 4 | |a Lyme Disease | |
| 650 | 4 | |a Mice | |
| 650 | 4 | |a Mice, Inbred AKR | |
| 650 | 4 | |a Mice, Inbred BALB C | |
| 650 | 4 | |a Mice, SCID | |
| 650 | 4 | |a Rabbits | |
| 650 | 4 | |a Recombinant Fusion Proteins | |
| 650 | 4 | |a Ticks | |
| 650 | 4 | |a Vaccination | |
| 650 | 4 | |a Vaccines, Synthetic | |
| 700 | 1 | |a Gern, Lisa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stehle, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Museteanu, Crisan |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Wallich, Reinhard |e VerfasserIn |0 (DE-588)1059566710 |0 (DE-627)798640839 |0 (DE-576)163467781 |4 aut | |
| 700 | 1 | |a Simon, Markus M. |e VerfasserIn |4 aut | |
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