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Plasmacytoid dendritic cells: neglected regulators of the immune response to Staphylococcus aureus

Plasmacytoid dendritic cells (pDC) are a rare subset of leukocytes equipped with Fcgamma and Fcepsilon receptors, which exert contrary effects on sensing of microbial nucleic acids by endosomal Toll-like receptors. In this article we explain how pDC contribute to the immune response to Staphylococcu...

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Bibliographic Details
Main Authors: Bekeredjian-Ding, Isabelle (Author) , Greil, Johann (Author) , Ammann, Sandra (Author) , Parcina, Marijo (Author)
Format: Article (Journal)
Language:English
Published: 23 May 2014
In: Frontiers in immunology
Year: 2014, Volume: 5, Pages: 1-10
ISSN:1664-3224
DOI:10.3389/fimmu.2014.00238
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fimmu.2014.00238
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2014.00238/full
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Author Notes:Isabelle Bekeredjian-Ding, Johann Greil, Sandra Ammann and Marijo Parcina
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Summary:Plasmacytoid dendritic cells (pDC) are a rare subset of leukocytes equipped with Fcgamma and Fcepsilon receptors, which exert contrary effects on sensing of microbial nucleic acids by endosomal Toll-like receptors. In this article we explain how pDC contribute to the immune response to Staphylococcus aureus. Under normal circumstances the pDC participates in the memory response to the pathogen: pDC activation is initiated by uptake of staphylococcal immune complexes with IgG or IgE. However, protein A-expressing S. aureus strains additionally trigger pDC activation in the absence of immunoglobulin. In this context staphylococci exploit the pDC to induce antigen-independent differentiation of IL-10 producing plasmablasts, an elegant means to propagate immune evasion. We further discuss the role of type I interferons in infection with S. aureus and the implications of these findings for the development of immune based therapies and vaccination.
Item Description:Gesehen am 17.02.2021
Physical Description:Online Resource
ISSN:1664-3224
DOI:10.3389/fimmu.2014.00238

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