Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk
Background: Whether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome. - Methods: We utili...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 23, 2020
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| In: |
Cancer epidemiology, biomarkers & prevention
Year: 2020, Volume: 29, Issue: 12, Pages: 2735-2739 |
| ISSN: | 1538-7755 |
| DOI: | 10.1158/1055-9965.EPI-20-0651 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1055-9965.EPI-20-0651 Verlag, lizenzpflichtig, Volltext: https://cebp.aacrjournals.org/content/29/12/2735 
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| Author Notes: | Dalia H. Ghoneim, Federico Canzian, Thilo Hackert [und 74 weitere] |
| Summary: | Background: Whether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome. - Methods: We utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data. - Results: Using genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: linoleic acid odds ratio (OR) = 1.00, 95% confidence interval (CI) = 0.98-1.02; arachidonic acid OR = 1.00, 95% CI = 0.99-1.01; and dihomo-gamma-linolenic acid OR = 0.95, 95% CI = 0.87-1.02]. The OR estimates remained virtually unchanged after adjustment for covariates, using individual-level data or summary statistics, or stratification by age and sex. - Conclusions: Our results suggest that variations of genetically determined plasma n-6 PUFA levels are not associated with pancreatic cancer risk. - Impact: These results suggest that modifying n-6 PUFA levels through food sources or supplementation may not influence risk of pancreatic cancer. |
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| Item Description: | Gesehen am 18.02.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1538-7755 |
| DOI: | 10.1158/1055-9965.EPI-20-0651 |