Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3
Abstract. The serine/threonine protein phosphatase (PP) 2A inhibitor, microcystin-LR, selectively induces liver damage and promotes hepatocarcinogenesis. It is thought that microcystin-LR affects hepatocellular viability mainly through inhibition of PP2A, partially through PP1, and, in addition, by...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 March 2007
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| In: |
Toxicological sciences
Year: 2007, Volume: 97, Issue: 2, Pages: 407-416 |
| ISSN: | 1096-0929 |
| DOI: | 10.1093/toxsci/kfm054 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/toxsci/kfm054 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/toxsci/article/97/2/407/1650613 
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| Author Notes: | Masaharu Komatsu, Tatsuhiko Furukawa, Ryuji Ikeda, Shota Takumi, Qingqing Nong, Kohji Aoyama, Shin-ichi Akiyama, Dietrich Keppler, and Toru Takeuchi |
| Summary: | Abstract. The serine/threonine protein phosphatase (PP) 2A inhibitor, microcystin-LR, selectively induces liver damage and promotes hepatocarcinogenesis. It is thought that microcystin-LR affects hepatocellular viability mainly through inhibition of PP2A, partially through PP1, and, in addition, by generation of reactive oxygen species (ROS). |
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| Item Description: | Gesehen am 18.02.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1096-0929 |
| DOI: | 10.1093/toxsci/kfm054 |