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Desmosine-inspired cross-linkers for hyaluronan hydrogels

We designed bioinspired cross-linkers based on desmosine, the cross-linker in natural elastin, to prepare hydrogels with thiolated hyaluronic acid. These short, rigid cross-linkers are based on pyridinium salts (as in desmosine) and can connect two polymer backbones. Generally, the obtained semi-syn...

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Main Authors: Hagel, Valentin (Author) , Wegner, Seraphine V. (Author) , Nuss, Isabell (Author) , Haraszti, Tamás (Author) , Spatz, Joachim P. (Author) , Böhm, Heike (Author)
Format: Article (Journal)
Language:English
Published: 20 June 2013
In: Scientific reports
Year: 2013, Volume: 3
ISSN:2045-2322
DOI:10.1038/srep02043
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/srep02043
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/srep02043
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Author Notes:Valentin Hagel, Markus Mateescu, Alexander Southan, Seraphine V. Wegner, Isabell Nuss, Tamás Haraszti, Claudia Kleinhans, Christian Schuh, Joachim P. Spatz, Petra J. Kluger, Monika Bach, Stefan Tussetschläger, Günter E. M. Tovar, Sabine Laschat & Heike Boehm
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Summary:We designed bioinspired cross-linkers based on desmosine, the cross-linker in natural elastin, to prepare hydrogels with thiolated hyaluronic acid. These short, rigid cross-linkers are based on pyridinium salts (as in desmosine) and can connect two polymer backbones. Generally, the obtained semi-synthetic hydrogels are form-stable, can withstand repeated stress, have a large linear-elastic range and show strain stiffening behavior typical for biopolymer networks. In addition, it is possible to introduce a positive charge to the core of the cross-linker without affecting the gelation efficiency, or consequently the network connectivity. However, the mechanical properties strongly depend on the charge of the cross-linker. The properties of the presented hydrogels can thus be tuned in a range important for engineering of soft tissues by controlling the cross-linking density and the charge of the cross-linker.
Item Description:Gesehen am 23.02.2021
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/srep02043

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