Cofilin peptide homologs interfere with immunological synapse formation and T cell activation
The formation of supramolecular activation clusters within the immunological synapse, crucial for sustained signaling and T lymphocyte activation, requires costimulation-dependent reorganization of the actin cytoskeleton. Here we have identified the actin-remodeling protein cofilin as a key player i...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 3, 2004
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| In: |
Proceedings of the National Academy of Sciences of the United States of America
Year: 2004, Volume: 101, Issue: 7, Pages: 1957-1962 |
| ISSN: | 1091-6490 |
| DOI: | 10.1073/pnas.0308282100 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1073/pnas.0308282100 Verlag, lizenzpflichtig, Volltext: https://www.pnas.org/content/101/7/1957 
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| Author Notes: | Sybille M. Eibert, Kyeong-Hee Lee, Rüdiger Pipkorn, Urban Sester, Guido H. Wabnitz, Thomas Giese, Stefan C. Meuer, and Yvonne Samstag |
| Summary: | The formation of supramolecular activation clusters within the immunological synapse, crucial for sustained signaling and T lymphocyte activation, requires costimulation-dependent reorganization of the actin cytoskeleton. Here we have identified the actin-remodeling protein cofilin as a key player in this process. Cell-permeable peptides that block costimulation-induced cofilin/F-actin interactions in untransformed human T lymphocytes impair receptor capping and immunological synapse formation at the interface between T cells and antigen-presenting cells. As a consequence, T cell activation, as measured by cytokine production and proliferation, is inhibited. |
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| Item Description: | Gesehen am 22.02.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1091-6490 |
| DOI: | 10.1073/pnas.0308282100 |