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Dephosphorylation of cofilin is regulated through Ras and requires the combined activities of the Ras-effectors MEK and PI3K

Remodeling of the actin cytoskeleton is crucial for a multitude of cellular functions including cell movement, intracellular transport as well as signal transduction and gene expression processes. Cofilin has been identified as a key mediator of actin reorganization. Its activity is regulated via re...

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Bibliographic Details
Main Authors: Nebl, Gabriele (Author) , Fischer, Sabine (Author) , Penzel, Roland (Author) , Samstag, Yvonne (Author)
Format: Article (Journal)
Language:English
Published: 2004
In: Cellular signalling
Year: 2004, Volume: 16, Issue: 2, Pages: 235-243
ISSN:1873-3913
DOI:10.1016/s0898-6568(03)00133-5
Online Access:Verlag, lizenzpflichtig, Volltext: http://dx.doi.org/10.1016/s0898-6568(03)00133-5
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0898656803001335
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Author Notes:Gabriele Nebl, Sabine Fischer, Roland Penzel, Yvonne Samstag
Description
Summary:Remodeling of the actin cytoskeleton is crucial for a multitude of cellular functions including cell movement, intracellular transport as well as signal transduction and gene expression processes. Cofilin has been identified as a key mediator of actin reorganization. Its activity is regulated via reversible phosphorylation of ser-3. In a variety of cell types stimulation through particular surface receptors fastly induces the dephosphorylation/activation of cofilin. Yet, the signal transduction cascades linking receptor stimulation with cofilin activation have not been identified so far. Here we show that the GTPase Ras acts as a central regulator of the cofilin dephosphorylation pathway. Thus, stimulation of Ras through platelet-derived growth factor (PDGF) or transient expression of activated Ras-proteins induces the dephosphorylation of cofilin. Importantly, the cooperation of two Ras-initiated signaling pathways is required to induce cofilin dephosphorylation: a Ras-Raf-MAPkinase/Erk-kinase (MEK)- and a Ras-phosphatidylinositol-3-kinase (PI3K)-effector cascade.
Item Description:Gesehen am 22.02.2021
Physical Description:Online Resource
ISSN:1873-3913
DOI:10.1016/s0898-6568(03)00133-5

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