Main- and branch-duct intraductal papillary mucinous neoplasms: extent of surgical resection
Background: Surgical treatment of intraductal papillary mucinous neoplasms (IPMN) requires a differentiated approach regarding indications and extent of resection. Methods: The review summarizes the current literature on indication, timing, and surgical procedures in IPMN. Results: The most importan...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 9, 2015
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| In: |
Viszeralmedizin
Year: 2015, Volume: 31, Issue: 1, Pages: 38-42 |
| ISSN: | 1662-6672 |
| DOI: | 10.1159/000375111 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000375111 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/375111 
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| Author Notes: | Thilo Hackert, Stefan Fritz, Markus W. Büchler |
| Summary: | Background: Surgical treatment of intraductal papillary mucinous neoplasms (IPMN) requires a differentiated approach regarding indications and extent of resection. Methods: The review summarizes the current literature on indication, timing, and surgical procedures in IPMN. Results: The most important differentiation has to be made between main-duct and branch-duct IPMN as well as mixed-type lesions that biologically mimic main-duct types. In main-duct and mixed-type IPMN, the resection should be indicated by the time of the diagnosis - in accordance with the international consensus guidelines - and should follow oncological principles. Depending on IPMN localization, this implies partial pancreatoduodenectomy, distal pancreatectomy, or total pancreatectomy and includes the corresponding types of lymphadenectomy. Furthermore, branch-duct IPMN > 3 cm or bearing high-risk features (mural nodules in magnetic resonance imaging, computed tomography, or endoscopic ultrasound imaging; symptomatic lesions; elevated tumor markers) are similarly treated. As the risk for malignancy in smaller branch-duct IPMN is lower, the decision for surgical treatment is often individually made - despite the updated 2012 guidelines. In these lesions, limited surgical approaches, including enucleation and central pancreatectomy, are possible. Conclusion: Timely and radical resection of IPMN offers the unique opportunity to prevent pancreatic cancer, and even in malignant IPMN surgery can offer a curative approach with excellent long-term outcome in early stages. A structured imaging follow-up should be considered to recognize IPMN recurrence and metachronous pancreatic cancer as well as gastrointestinal neoplasias by endoscopic surveillance. |
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| Item Description: | Gesehen am 23.02.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1662-6672 |
| DOI: | 10.1159/000375111 |