In vivo evaluation of combined CK2 inhibition and irradiation in human WiDr tumours
Background/Aim: Casein kinase 2 (CK2) which sustains multiple pro-survival functions in cellular DNA-damage response, is strictly regulated in normal cells but elevated in cancer. CK2 is considered as a potential therapeutic target, and its inhibition has been associated with radiosensitization in m...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 5, 2021
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| In: |
In vivo
Year: 2021, Volume: 35, Issue: 1, Pages: 111-117 |
| ISSN: | 1791-7549 |
| DOI: | 10.21873/invivo.12238 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/invivo.12238 Verlag, lizenzpflichtig, Volltext: https://iv.iiarjournals.org/content/35/1/111 
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| Author Notes: | Felix Zwicker, Henrik Hauswald, Klaus-Josef Weber, Jürgen Debus and Peter E. Huber |
MARC
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| 245 | 1 | 0 | |a In vivo evaluation of combined CK2 inhibition and irradiation in human WiDr tumours |c Felix Zwicker, Henrik Hauswald, Klaus-Josef Weber, Jürgen Debus and Peter E. Huber |
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| 520 | |a Background/Aim: Casein kinase 2 (CK2) which sustains multiple pro-survival functions in cellular DNA-damage response, is strictly regulated in normal cells but elevated in cancer. CK2 is considered as a potential therapeutic target, and its inhibition has been associated with radiosensitization in mammalian cells in vitro. Here, we investigated potential radiosensitization by CK2 inhibition in vivo. Materials and Methods: The effect of CK2 inhibition in vivo was investigated in human WiDr-xenograft tumours grown subcutaneously on BALB/c nu/nu mice with and without fractionated irradiation. CK2 inhibition was performed using the specific inhibitor tetra-bromobenzotriazole (TBB). Histological examinations included staining for apoptosis and double-strand breaks. Results: Both TBB treatment alone and radiation alone significantly reduced tumour growth, which was reflected by increased apoptosis rates. However, TBB treatment did not boost radiation-induced tumour growth suppression in combined treatment, although the apoptosis rate increased and repair of double-strand breaks was reduced. This was in stark contrast to previous data on in vitro radiosensitization. Conclusion: The absence of radiosensitization by CK2 inhibition should be investigated in different tumour models. | ||
| 650 | 4 | |a CK2 inhibition | |
| 650 | 4 | |a human WiDr tumours | |
| 650 | 4 | |a irradiation | |
| 650 | 4 | |a TBB | |
| 650 | 4 | |a tetra-bromobenzotriazole | |
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| 700 | 1 | |a Weber, Klaus-Josef |d 1951- |e VerfasserIn |0 (DE-588)112804373 |0 (DE-627)691161224 |0 (DE-576)289743125 |4 aut | |
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| 700 | 1 | |a Huber, Peter E. |d 1965- |e VerfasserIn |0 (DE-588)1074678869 |0 (DE-627)832350109 |0 (DE-576)442767803 |4 aut | |
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