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Proinflammatory T cell polarization is already present in patients with early knee osteoarthritis

Investigating the pathophysiological mechanisms of early osteoarthritis (OA) is of utmost interest since this stage holds the strongest promise for therapeutic interventions. The aims of this study were to analyze if synovial inflammation is already present in early OA and to characterize the involv...

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Main Authors: Rosshirt, Nils (Author) , Trauth, Richard (Author) , Platzer, Hadrian (Author) , Tripel, Elena (Author) , Nees, Timo A. (Author) , Lorenz, Hanns-Martin (Author) , Tretter, Theresa (Author) , Moradi, Babak (Author)
Format: Article (Journal)
Language:English
Published: 22 January 2021
In: Arthritis Research & Therapy
Year: 2021, Volume: 23
ISSN:1465-9913
DOI:10.1186/s13075-020-02410-w
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13075-020-02410-w
Verlag, kostenfrei, Volltext: https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-020-02410-w
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Author Notes:Nils Rosshirt, Richard Trauth, Hadrian Platzer, Elena Tripel, Timo A. Nees, Hanns-Martin Lorenz, Theresa Tretter and Babak Moradi
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Summary:Investigating the pathophysiological mechanisms of early osteoarthritis (OA) is of utmost interest since this stage holds the strongest promise for therapeutic interventions. The aims of this study were to analyze if synovial inflammation is already present in early OA and to characterize the involved cell populations, by investigating synovial fluid (SF) and synovial membrane (SM) of early OA patients for the presence and polarization status of CD4 T cells.
Item Description:Gesehen am 24.02.2021
Physical Description:Online Resource
ISSN:1465-9913
DOI:10.1186/s13075-020-02410-w

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