Gold meets rhodium: tandem one-pot synthesis of β-disubstituted ketones via Meyer-Schuster rearrangement and asymmetric 1,4-addition
An asymmetric one-pot tandem Au/Rh-catalyzed synthesis of highly enantioenriched β-disubstituted ketones starting from racemic propargyl alcohols is disclosed. The compatibility of the two metal complexes (Au/Rh) and their orthogonal ligand systems (NHC/diene) in this bimetallic catalytic system is...
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| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
06/18/2013
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| In: |
Organic letters
Year: 2013, Volume: 15, Issue: 13, Pages: 3226-3229 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/ol4011739 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/ol4011739
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| Author Notes: | Max M. Hansmann, A. Stephen K. Hashmi, and Mark Lautens |