The CD95(APO-1/Fas) DISC and beyond
CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 March 2003
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| In: |
Cell death and differentiation
Year: 2003, Volume: 10, Pages: 26-35 |
| ISSN: | 1476-5403 |
| DOI: | 10.1038/sj.cdd.4401186 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.cdd.4401186 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/4401186 
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| Author Notes: | M.E. Peter and P.H. Krammer |
| Summary: | CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. A number of proteins have been reported to regulate formation or activity of the DISC. This review discusses recent developments in this area of death receptor research. |
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| Item Description: | Gesehen am 02.03.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1476-5403 |
| DOI: | 10.1038/sj.cdd.4401186 |