Regulation of T cell apoptosis during the immune response
Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire selection during T cell maturation and homeostasis of the immune system. It also plays a key role in elimination of autoreactive lymphocytes. Resting mature T cells are activated by antigen to elicit an approp...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2002
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| In: |
Current molecular medicine
Year: 2002, Volume: 2, Issue: 3, Pages: 257-272 |
| ISSN: | 1875-5666 |
| DOI: | 10.2174/1566524024605671 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.2174/1566524024605671 Verlag, lizenzpflichtig, Volltext: http://www.benthamdirect.com/64648/article 
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| Author Notes: | Sven Baumann, Andreas Krueger, Sabine Kirchhoff und Peter H. Krammer |
| Summary: | Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire selection during T cell maturation and homeostasis of the immune system. It also plays a key role in elimination of autoreactive lymphocytes. Resting mature T cells are activated by antigen to elicit an appropriate immune response. In contrast, preactivated T cells undergo activation-induced cell death (AICD) in response to TCR triggering alone. Thus, death by apoptosis is essential for function, growth and differentiation of T-lymphocytes. This review focuses on apoptosis mechanisms involved in T cell development and during the course of an immune response. |
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| Item Description: | Gesehen am 03.03.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1875-5666 |
| DOI: | 10.2174/1566524024605671 |