Transforming growth factor β can mediate apoptosis via the expression of TRAIL in human hepatoma cells
Transforming growth factor β (TGF-β) has been shown to induce apoptotic cell death in normal and transformed hepatocytes. However, the exact mechanism through which TGF-β induces cell death is still unknown. We examined a potential role of various death receptor/ligand systems in TGF-β-induced apopt...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
16 June 2005
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| In: |
Hepatology
Year: 2005, Volume: 42, Issue: 1, Pages: 183-192 |
| ISSN: | 1527-3350 |
| DOI: | 10.1002/hep.20757 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/hep.20757 Verlag, lizenzpflichtig, Volltext: https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.20757 
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| Author Notes: | Kerstin Herzer, Tom M. Ganten, Henning Schulze‐Bergkamen, Anne Grosse‐Wilde, Ronald Koschny, Peter H. Krammer, and Henning Walczak |
| Summary: | Transforming growth factor β (TGF-β) has been shown to induce apoptotic cell death in normal and transformed hepatocytes. However, the exact mechanism through which TGF-β induces cell death is still unknown. We examined a potential role of various death receptor/ligand systems in TGF-β-induced apoptosis and identified the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a mediator of TGF-β-induced apoptosis in hepatoma cells. TGF-β-induced apoptosis is significantly impaired upon blockage of TRAIL. We show that TRAIL is upregulated in hepatoma cells upon treatment with TGF-β, whereas TRAIL receptor levels remain unchanged. In conclusion, our results provide evidence that the TRAIL system is critically involved in TGF-β-induced cell death in liver pathology. |
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| Item Description: | Gesehen am 04.03.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1527-3350 |
| DOI: | 10.1002/hep.20757 |