Mechanosensitive TREK-1 two-pore-domain potassium (K2P) channels in the cardiovascular system
TWIK-related K+ channel (TREK-1) two-pore-domain potassium (K2P) channels mediate background potassium currents and regulate cellular excitability in many different types of cells. Their functional activity is controlled by a broad variety of different physiological stimuli, such as temperature, ext...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2021
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| In: |
Progress in biophysics & molecular biology
Year: 2020, Volume: 159, Pages: 126-135 |
| ISSN: | 1873-1732 |
| DOI: | 10.1016/j.pbiomolbio.2020.05.007 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.pbiomolbio.2020.05.007 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0079610720300432 
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| Author Notes: | Felix Wiedmann, Susanne Rinné, Birgit Donner, Niels Decher, Hugo A. Katus, Constanze Schmidt |
| Summary: | TWIK-related K+ channel (TREK-1) two-pore-domain potassium (K2P) channels mediate background potassium currents and regulate cellular excitability in many different types of cells. Their functional activity is controlled by a broad variety of different physiological stimuli, such as temperature, extracellular or intracellular pH, lipids and mechanical stress. By linking cellular excitability to mechanical stress, TREK-1 currents might be important to mediate parts of the mechanoelectrical feedback described in the heart. Furthermore, TREK-1 currents might contribute to the dysregulation of excitability in the heart in pathophysiological situations, such as those caused by abnormal stretch or ischaemia-associated cell swelling, thereby contributing to arrhythmogenesis. In this review, we focus on the functional role of TREK-1 in the heart and its putative contribution to cardiac mechanoelectrical coupling. Its cardiac expression among different species is discussed, alongside with functional evidence for TREK-1 currents in cardiomyocytes. In addition, evidence for the involvement of TREK-1 currents in different cardiac arrhythmias, such as atrial fibrillation or ventricular tachycardia, is summarized. Furthermore, the role of TREK-1 and its interaction partners in the regulation of the cardiac heart rate is reviewed. Finally, we focus on the significance of TREK-1 in the development of cardiac hypertrophy, cardiac fibrosis and heart failure. |
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| Item Description: | Im Titel ist 2P tiefgestellt Available online 15 June 2020 Gesehen am 05.03.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1873-1732 |
| DOI: | 10.1016/j.pbiomolbio.2020.05.007 |