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CaM kinase II-δ is required for diabetic hyperglycemia and retinopathy but not nephropathy

Type 2 diabetes has become a pandemic and leads to late diabetic complications of organs, including kidney and eye. Lowering hyperglycemia is the typical therapeutic goal in clinical medicine. However, hyperglycemia may only be a symptom of diabetes but not the sole cause of late diabetic complicati...

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Main Authors: Chen, Jessy (Author) , Fleming, Thomas (Author) , Katz, Sylvia (Author) , Dewenter, Matthias (Author) , Hofmann, Kai (Author) , Saadatmand, Ali R. (Author) , Kronlage, Mariya (Author) , Werner, Moritz P. (Author) , Pokrandt, Bianca (Author) , Schreiter, Friederike (Author) , Lin, Jihong (Author) , Katz, Daniel (Author) , Morgenstern, Jakob (Author) , Elwakiel, Ahmed (Author) , Sinn, Peter (Author) , Gröne, Hermann-Josef (Author) , Hammes, Hans-Peter (Author) , Nawroth, Peter Paul (Author) , Isermann, Berend (Author) , Sticht, Carsten (Author) , Brügger, Britta (Author) , Katus, Hugo (Author) , Hagenmueller, Marco (Author) , Backs, Johannes (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Diabetes
Year: 2020, Volume: 70, Issue: 2, Pages: 616-626
ISSN:1939-327X
DOI:10.2337/db19-0659
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2337/db19-0659
Verlag, lizenzpflichtig, Volltext: https://diabetes.diabetesjournals.org/content/70/2/616
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Author Notes:Jessy Chen, Thomas Fleming, Sylvia Katz, Matthias Dewenter, Kai Hofmann, Alireza Saadatmand, Mariya Kronlage, Moritz P. Werner, Bianca Pokrandt, Friederike Schreiter, Jihong Lin, Daniel Katz, Jakob Morgenstern, Ahmed Elwakiel, Peter Sinn, Hermann-Josef Gröne, Hans-Peter Hammes, Peter P. Nawroth, Berend Isermann, Carsten Sticht, Britta Brügger, Hugo A. Katus, Marco Hagenmueller and Johannes Backs
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Summary:Type 2 diabetes has become a pandemic and leads to late diabetic complications of organs, including kidney and eye. Lowering hyperglycemia is the typical therapeutic goal in clinical medicine. However, hyperglycemia may only be a symptom of diabetes but not the sole cause of late diabetic complications; instead, other diabetes-related alterations could be causative. Here, we studied the role of CaM kinase II-δ (CaMKIIδ), which is known to be activated through diabetic metabolism. CaMKIIδ is expressed ubiquitously and might therefore affect several different organ systems. We crossed diabetic leptin receptor-mutant mice to mice lacking CaMKIIδ globally. Remarkably, CaMKIIδ-deficient diabetic mice did not develop hyperglycemia. As potential underlying mechanisms, we provide evidence for improved insulin sensing with increased glucose transport into skeletal muscle and also reduced hepatic glucose production. Despite normoglycemia, CaMKIIδ-deficient diabetic mice developed the full picture of diabetic nephropathy, but diabetic retinopathy was prevented. We also unmasked a retina-specific gene expression signature that might contribute to CaMKII-dependent retinal diabetic complications. These data challenge the clinical concept of normalizing hyperglycemia in diabetes as a causative treatment strategy for late diabetic complications and call for a more detailed analysis of intracellular metabolic signals in different diabetic organs.
Item Description:Epub 2020 Nov 25
Gesehen am 05.03.2021
Physical Description:Online Resource
ISSN:1939-327X
DOI:10.2337/db19-0659

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