Cyclosporin A: resistant transactivation of the IL-2 promoter requires activity of okadaic acid-sensitive aerine/threonine phosphatases
Expression of the IL-2 gene requires activation of T cells through stimulation of the TCR and costimulation through accessory receptors. We have found recently that okadaic acid-sensitive Ser/Thr phosphatases are involved in a cyclosporin A-insensitive pathway that selectively transmits costimulator...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1998
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| In: |
The journal of immunology
Year: 1998, Volume: 161, Issue: 4, Pages: 1803-1810 |
| ISSN: | 1550-6606 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://www.jimmunol.org/content/161/4/1803
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| Author Notes: | Gabriele Nebl, Stefan C. Meuer and Yvonne Samstag |
| Summary: | Expression of the IL-2 gene requires activation of T cells through stimulation of the TCR and costimulation through accessory receptors. We have found recently that okadaic acid-sensitive Ser/Thr phosphatases are involved in a cyclosporin A-insensitive pathway that selectively transmits costimulatory signals. In this study, we analyzed whether activities of these phosphatases are necessary for the expression of the IL-2 gene. In both activated peripheral blood T lymphocytes and activated tumorigenic T cell lines, IL-2 gene expression was blocked at the transcriptional level by okadaic acid. The transcription factors active at the IL-2 promoter were differentially influenced: upon down-modulation of okadaic acid-sensitive phosphatases, transactivation by octamer, NF-κB, and NF of activated T cells proteins was abrogated, while transactivation by AP-1 proteins was even enhanced. |
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| Item Description: | Published online: August 15, 1998 Gesehen am 08.03.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1550-6606 |