C332C genotype of glyoxalase 1 and its association with late diabetic complications: Glo1 genotype and diabetic neuropathy
<p>Glyoxalase 1 catalyses the detoxification of methylglyoxal, a major precursor of advanced glycation end products associated with aging, neurodegenerative diseases, and microvascular complications of diabetes. Here, we examine a possible association of a single nucleotide polymorphism of gly...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
17. Juni 2013
|
| In: |
Experimental and clinical endocrinology & diabetes
Year: 2013, Volume: 121, Issue: 7, Pages: 436-439 |
| ISSN: | 1439-3646 |
| DOI: | 10.1055/s-0033-1345124 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1055/s-0033-1345124 Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1345124 
|
| Author Notes: | J.B. Groener, P. Reismann, T. Fleming, H. Kalscheuer, D. Lehnhoff, A. Hamann, P. Roser, A. Bierhaus, P.P. Nawroth, G. Rudofsky |
| Summary: | <p>Glyoxalase 1 catalyses the detoxification of methylglyoxal, a major precursor of advanced glycation end products associated with aging, neurodegenerative diseases, and microvascular complications of diabetes. Here, we examine a possible association of a single nucleotide polymorphism of glyoxalase 1 gene (Glo1 A332C, rs4746 or rs2736654) with the prevalence of microvascular diabetic complications in patients with type 1 and type 2 diabetes.</p> <p>Genotyping was performed in 209 patients with type 1 and 524 patients with type 2 diabetes using polymerase chain reaction and subsequent cleavage by restriction endonuclease Bsa I.</p> <p>Frequencies of the glyoxalase 1 genotypes were different with respect to diabetes type with a significantly higher prevalence of A332A-genotype in type 1 diabetes (35.9% vs. 27.3%; p=0.03). In type 1 diabetes, there was no correlation of any genotype with diabetic retinopathy, nephropathy or neuropathy. In contrast, type 2 diabetic patients homozygous for the C332C allele showed a significantly increased prevalence of diabetic neuropathy (p=0.03; OR=1.49 [95%-CI: 1.04; 2.11]), while no association with diabetic nephropathy or retinopathy was found. However, the significance of this association was lost after correction for multiple testing.</p> <p>Our data suggest a possible association of C332C-genotype of the glyoxalase 1 gene with diabetic neuropathy in type 2 diabetes, supporting the hypothesis that methylglyoxal might be an important mediator of diabetic neuropathy in type 2 diabetes.</p> |
|---|---|
| Item Description: | Gesehen am 10.03.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1439-3646 |
| DOI: | 10.1055/s-0033-1345124 |