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Analysis of interleukin-1β-modulated mRNA gene transcription in human gingival keratinocytes by epithelia-specific cDNA microarrays

Proinflammatory cytokines such as interleukin-1β are known to be synthesized in oral gingivitis and periodontitis and lead to the activation of the transcription factor nuclear factor-κB (NF-κB). Although numerous effects of interleukin-1β on mesenchymal cells are known, e.g. up-regulation of interc...

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Main Authors: Steinberg, Thorsten (Author) , Dannewitz, Bettina (Author) , Tomakidi, Pascal (Author) , Hoheisel, Jörg D. (Author) , Wörtche, Eva (Author) , Kohl, Annette (Author) , Nees, M. (Author)
Format: Article (Journal)
Language:English
Published: 29 August 2006
In: Journal of periodontal research
Year: 2006, Volume: 41, Issue: 5, Pages: 426-446
ISSN:1600-0765
DOI:10.1111/j.1600-0765.2006.00884.x
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0765.2006.00884.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0765.2006.00884.x
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Author Notes:T. Steinberg, B. Dannewitz, P. Tomakidi, J.D. Hoheisel, E. Müssig, A. Kohl, M. Nees
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Summary:Proinflammatory cytokines such as interleukin-1β are known to be synthesized in oral gingivitis and periodontitis and lead to the activation of the transcription factor nuclear factor-κB (NF-κB). Although numerous effects of interleukin-1β on mesenchymal cells are known, e.g. up-regulation of intercellular adhesion moelcule-1 in endothelial cells, little is known of the effects of interleukin-1β on oral keratinocytes. The purpose of the present study was to seek interleukin-1β-mediated alterations in mRNA gene transcription and a putative activation of NF-κB in oral gingival keratinocytes.
Item Description:Gesehen am 10.03.2021
Physical Description:Online Resource
ISSN:1600-0765
DOI:10.1111/j.1600-0765.2006.00884.x

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