Analysis of interleukin-1β-modulated mRNA gene transcription in human gingival keratinocytes by epithelia-specific cDNA microarrays
Proinflammatory cytokines such as interleukin-1β are known to be synthesized in oral gingivitis and periodontitis and lead to the activation of the transcription factor nuclear factor-κB (NF-κB). Although numerous effects of interleukin-1β on mesenchymal cells are known, e.g. up-regulation of interc...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 August 2006
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| In: |
Journal of periodontal research
Year: 2006, Jahrgang: 41, Heft: 5, Pages: 426-446 |
| ISSN: | 1600-0765 |
| DOI: | 10.1111/j.1600-0765.2006.00884.x |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0765.2006.00884.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0765.2006.00884.x 
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| Verfasserangaben: | T. Steinberg, B. Dannewitz, P. Tomakidi, J.D. Hoheisel, E. Müssig, A. Kohl, M. Nees |
| Zusammenfassung: | Proinflammatory cytokines such as interleukin-1β are known to be synthesized in oral gingivitis and periodontitis and lead to the activation of the transcription factor nuclear factor-κB (NF-κB). Although numerous effects of interleukin-1β on mesenchymal cells are known, e.g. up-regulation of intercellular adhesion moelcule-1 in endothelial cells, little is known of the effects of interleukin-1β on oral keratinocytes. The purpose of the present study was to seek interleukin-1β-mediated alterations in mRNA gene transcription and a putative activation of NF-κB in oral gingival keratinocytes. |
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| Beschreibung: | Gesehen am 10.03.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1600-0765 |
| DOI: | 10.1111/j.1600-0765.2006.00884.x |