"Hit and run" therapy averts macular degeneration
Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration.
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 February 2021
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| In: |
Nature biomedical engineering
Year: 2021, Volume: 5, Issue: 2, Pages: 132-133 |
| ISSN: | 2157-846X |
| DOI: | 10.1038/s41551-021-00690-4 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41551-021-00690-4 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41551-021-00690-4 
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| Author Notes: | Felix Bubeck & Dirk Grimm |
| Summary: | Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration. |
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| Item Description: | Gesehen am 01.12.2021 |
| Physical Description: | Online Resource |
| ISSN: | 2157-846X |
| DOI: | 10.1038/s41551-021-00690-4 |