"Hit and run" therapy averts macular degeneration
Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration.
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 February 2021
|
| In: |
Nature biomedical engineering
Year: 2021, Volume: 5, Issue: 2, Pages: 132-133 |
| ISSN: | 2157-846X |
| DOI: | 10.1038/s41551-021-00690-4 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41551-021-00690-4 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41551-021-00690-4 
|
| Author Notes: | Felix Bubeck & Dirk Grimm |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1751083810 | ||
| 003 | DE-627 | ||
| 005 | 20220819133000.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210311s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41551-021-00690-4 |2 doi | |
| 035 | |a (DE-627)1751083810 | ||
| 035 | |a (DE-599)KXP1751083810 | ||
| 035 | |a (OCoLC)1341398298 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bubeck, Felix |d 1992- |e VerfasserIn |0 (DE-588)1172685525 |0 (DE-627)104131955X |0 (DE-576)514732695 |4 aut | |
| 245 | 1 | 0 | |a "Hit and run" therapy averts macular degeneration |c Felix Bubeck & Dirk Grimm |
| 264 | 1 | |c 12 February 2021 | |
| 300 | |a 2 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.12.2021 | ||
| 520 | |a Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration. | ||
| 700 | 1 | |a Grimm, Dirk |e VerfasserIn |0 (DE-588)1016476671 |0 (DE-627)70553376X |0 (DE-576)352260645 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature biomedical engineering |d London : Nature Research, 2016 |g 5(2021), 2, Seite 132-133 |h Online-Ressource |w (DE-627)875699383 |w (DE-600)2878897-7 |w (DE-576)481341943 |x 2157-846X |7 nnas |a "Hit and run" therapy averts macular degeneration |
| 773 | 1 | 8 | |g volume:5 |g year:2021 |g number:2 |g pages:132-133 |g extent:2 |a "Hit and run" therapy averts macular degeneration |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41551-021-00690-4 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41551-021-00690-4 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210311 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1016476671 |a Grimm, Dirk |m 1016476671:Grimm, Dirk |d 910000 |d 911700 |e 910000PG1016476671 |e 911700PG1016476671 |k 0/910000/ |k 1/910000/911700/ |p 2 |y j | ||
| 998 | |g 1172685525 |a Bubeck, Felix |m 1172685525:Bubeck, Felix |d 910000 |d 911700 |e 910000PB1172685525 |e 911700PB1172685525 |k 0/910000/ |k 1/910000/911700/ |p 1 |x j | ||
| 999 | |a KXP-PPN1751083810 |e 3884697935 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Felix Bubeck & Dirk Grimm"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1751083810","title":[{"title":"\"Hit and run\" therapy averts macular degeneration","title_sort":"\"Hit and run\" therapy averts macular degeneration"}],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"12 February 2021"}],"id":{"doi":["10.1038/s41551-021-00690-4"],"eki":["1751083810"]},"relHost":[{"part":{"year":"2021","pages":"132-133","text":"5(2021), 2, Seite 132-133","extent":"2","issue":"2","volume":"5"},"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["Volume: 1 (2016)-"],"recId":"875699383","title":[{"title":"Nature biomedical engineering","title_sort":"Nature biomedical engineering"}],"disp":"\"Hit and run\" therapy averts macular degenerationNature biomedical engineering","origin":[{"dateIssuedKey":"2016","publisher":"Nature Research","dateIssuedDisp":"2016-","publisherPlace":"London ; New York NY ; Tokyo"}],"id":{"issn":["2157-846X"],"eki":["875699383"],"zdb":["2878897-7"]},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 29.12.16"]}],"physDesc":[{"extent":"2 S."}],"note":["Gesehen am 01.12.2021"],"person":[{"given":"Felix","role":"aut","display":"Bubeck, Felix","family":"Bubeck","roleDisplay":"VerfasserIn"},{"family":"Grimm","roleDisplay":"VerfasserIn","role":"aut","display":"Grimm, Dirk","given":"Dirk"}]} | ||
| SRT | |a BUBECKFELIHITANDRUNT1220 | ||