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Elevated peripheral leukocyte counts in acute cervical artery dissection

Background and purpose It has been suggested that inflammation may play a role in the development of cervical artery dissection (CeAD), but evidence remains scarce. Methods A total of 172 patients were included with acute (< 24 h) CeAD and 348 patients with acute ischaemic stroke (IS) of other (n...

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Main Authors: Grond-Ginsbach, Caspar (Author) , Giossi, A. (Author) , Aksay, Suna Su (Author) , Engelter, S. T. (Author) , Lyrer, P. A. (Author) , Metso, T. M. (Author) , Metso, A. J. (Author) , Tatlisumak, T. (Author) , Debette, S. (Author) , Leys, D. (Author) , Thijs, V. (Author) , Bersano, A. (Author) , Abboud, S. (Author) , Kloss, Manja (Author) , Lichy, Christoph (Author) , Grau, Armin J. (Author) , Pezzini, Alessandro (Author) , Touzé, E. (Author)
Format: Article (Journal)
Language:English
Published: 12 June 2013
In: European journal of neurology
Year: 2013, Volume: 20, Issue: 10, Pages: 1405-1410
ISSN:1468-1331
DOI:https://doi.org/10.1111/ene.12201
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1111/ene.12201
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.12201
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Author Notes:C. Grond‐Ginsbach, A. Giossi, S.S. Aksay, S.T. Engelter, P.A. Lyrer, T.M. Metso, A.J. Metso, T. Tatlisumak, S. Debette, D. Leys, V. Thijs, A. Bersano, S. Abboud, M. Kloss, C. Lichy, A. Grau, A. Pezzini and E. Touzé for the CADISP group
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Summary:Background and purpose It has been suggested that inflammation may play a role in the development of cervical artery dissection (CeAD), but evidence remains scarce. Methods A total of 172 patients were included with acute (< 24 h) CeAD and 348 patients with acute ischaemic stroke (IS) of other (non-CeAD) causes from the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study, and 223 age- and sex-matched healthy control subjects. White blood cell (WBC) counts collected at admission were compared across the three groups. Results Compared with healthy control subjects, CeAD patients and non-CeAD stroke patients had higher WBC counts (P < 0.001). Patients with CeAD had higher WBC counts and were more likely to have WBC > 10 000/μl than non-CeAD stroke patients (38.4% vs. 23.0%, P < 0.001) and healthy controls (38.4% vs. 8.5%, P < 0.001). WBC counts were higher in CeAD (9.4 ± 3.3) than in IS of other causes (large artery atherosclerosis, 8.7 ± 2.3; cardioembolism, 8.2 ± 2.8; small vessel disease, 8.4 ± 2.4; undetermined cause, 8.8 ± 3.1; P = 0.022). After adjustment for age, sex, stroke severity and vascular risk factors in a multiple regression model, elevated WBC count remained associated with CeAD, as compared with non-CeAD stroke patients [odds ratio (OR) = 2.56; 95% CI 1.60-4.11; P < 0.001) and healthy controls (OR = 6.27; 95% CI 3.39-11.61; P < 0.001). Conclusions Acute CeAD was associated with particularly high WBC counts. Leukocytosis may reflect a pre-existing inflammatory state, supporting the link between inflammation and CeAD.
Item Description:Gesehen am 11.03.2021
Physical Description:Online Resource
ISSN:1468-1331
DOI:https://doi.org/10.1111/ene.12201

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