Pain control by targeting oxidized phospholipids: functions, mechanisms, perspectives
Within the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, pain-inducing metabolites. They excite sensory, nociceptive neurons by activating transient receptor potential ion channels, s...
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 January 2021
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| In: |
Frontiers in endocrinology
Year: 2021, Volume: 11, Pages: 1-9 |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2020.613868 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fendo.2020.613868 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fendo.2020.613868/full 
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| Author Notes: | Beatrice Oehler, Alexander Brack, Robert Blum and Heike L. Rittner |
| Summary: | Within the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, pain-inducing metabolites. They excite sensory, nociceptive neurons by activating transient receptor potential ion channels, specifically TRPA1 and TRPV1. Under inflammatory conditions, OxPL-mediated receptor potentials even potentiate the action potential firing rate of nociceptors. Targeting OxPL with D-4F peptide or antibodies like E06 can be used to control acute, inflammatory pain syndromes. The basics of how OxPL operate as agonists and excitants are not completely understood: Due to the difficulties to stabilize and measure these highly reactive metabolites in a physiological context, it is not yet clear, how OxPL contribute to the many functions of the epilipidome in vivo. With a focus on proalgesic specificities of OxPL, this article discusses, how targeting defined substances of the lipidome can contribute to mechanism-based therapies against primary and secondary chronic inflammatory or possibly also neuropathic pain. |
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| Item Description: | Gesehen am 01.12.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2020.613868 |