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Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?

A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerbation of synovitis in RA, little is known about their influence on the...

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Main Authors: Kvacskay, Peter (Author) , Yao, Nina (Author) , Schnotz, Jürgen-Heinz (Author) , Scarpone, Roberta (Author) , Carvalho, Rui de Albuquerque (Author) , Klika, Karel D. (Author) , Merkt, Wolfgang (Author) , Tretter, Theresa (Author) , Lorenz, Hanns-Martin (Author) , Tykocinski, Lars-Oliver (Author)
Format: Article (Journal)
Language:English
Published: 15 February 2021
In: Arthritis Research & Therapy
Year: 2021, Volume: 23, Pages: 1-15
ISSN:1465-9913
DOI:10.1186/s13075-021-02437-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13075-021-02437-7
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Author Notes:Peter Kvacskay, Nina Yao, Jürgen-Heinz Schnotz, Roberta Scarpone, Rui de Albuquerque Carvalho, Karel D. Klika, Wolfgang Merkt, Theresa Tretter, Hanns-Martin Lorenz and Lars-Oliver Tykocinski
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Summary:A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerbation of synovitis in RA, little is known about their influence on the metabolism of SF. Thus, this study investigates the effect of Th cells on the glucose metabolism and phenotype of SF and how this is influenced by the blockade of cytokines, janus kinases (JAKs) and glycolysis.
Item Description:Gesehen am 30.11.2021
Physical Description:Online Resource
ISSN:1465-9913
DOI:10.1186/s13075-021-02437-7

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