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Stability of high-frequency (600 Hz) components in human somatosensory evoked potentials under variation of stimulus rate: evidence for a thalamic origin

The generators of spike-like high-frequency (600 Hz) wavelets superimposed on the primary cortical response (N20) in human median nerve somatosensory evoked potentials (SEP) have been localized anatomically both close to the primary somatosensory hand cortex and in deep axon segments of thalamo-cort...

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Bibliographic Details
Main Authors: Gobbelé, René (Author) , Buchner, H. (Author) , Scherg, Michael (Author) , Curio, G. (Author)
Format: Article (Journal)
Language:English
Published: 4 August 1999
In: Clinical neurophysiology
Year: 1999, Volume: 110, Issue: 9, Pages: 1659-1663
ISSN:1872-8952
DOI:10.1016/S1388-2457(99)00114-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S1388-2457(99)00114-5
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1388245799001145
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Author Notes:R. Gobbelé, H. Buchner, M. Scherg, G. Curio
Description
Summary:The generators of spike-like high-frequency (600 Hz) wavelets superimposed on the primary cortical response (N20) in human median nerve somatosensory evoked potentials (SEP) have been localized anatomically both close to the primary somatosensory hand cortex and in deep axon segments of thalamo-cortical projection neurons. Here, N20 and 600 Hz burst components were functionally dissociated by varying the stimulus rate (1.5, 3, 6, 9 Hz). The N20 source amplitudes were significantly reduced at the higher stimulus rates. In contrast, the source amplitudes of the 600 Hz oscillations remained stable across all stimulus rates. This reflects different source origins, confirming a postsynaptic intracortical generation of the N20 component and provides further evidence for a presynaptic origin of the 600 Hz activity like repetitive neuronal population spikes conducted in deep and superficial segments of thalamo-cortical projection fibers.
Item Description:Gesehen am 15.03.2021
Physical Description:Online Resource
ISSN:1872-8952
DOI:10.1016/S1388-2457(99)00114-5

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