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Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons

The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung. They play a role in innate and adaptive immunity and are targets for various bacterial and viral adhesins. Two pathogens that colonize t...

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Main Authors: Klaile, Esther (Author) , Klassert, Tilman (Author) , Scheffrahn, Inka (Author) , Müller, Mario (Author) , Heinrich, Annina (Author) , Heyl, Kerstin Andrea (Author) , Dienemann, Hendrik (Author) , Grünewald, Christiane (Author) , Bals, Robert (Author) , Singer, Bernhard Bonaventura (Author) , Slevogt, Hortense (Author)
Format: Article (Journal)
Language:English
Published: 14 August 2013
In: Respiratory research
Year: 2013, Volume: 14, Pages: 1-17
ISSN:1465-993X
DOI:10.1186/1465-9921-14-85
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1465-9921-14-85
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Author Notes:Esther Klaile, Tilman E Klassert, Inka Scheffrahn, Mario M Müller, Annina Heinrich, Kerstin A Heyl, Hendrik Dienemann, Christiane Grünewald, Robert Bals, Bernhard B Singer and Hortense Slevogt
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Summary:The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung. They play a role in innate and adaptive immunity and are targets for various bacterial and viral adhesins. Two pathogens that colonize the normally sterile lower respiratory tract in patients with chronic obstructive pulmonary disease (COPD) are non-typable Haemophilus influenzae (NTHI) and Moraxella catarrhalis. Both pathogens bind to CEACAMs and elicit a variety of cellular reactions, including bacterial internalization, cell adhesion and apoptosis.
Item Description:Gesehen am 22.06.2022
Physical Description:Online Resource
ISSN:1465-993X
DOI:10.1186/1465-9921-14-85

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