Buchumschlag

Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons

The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung. They play a role in innate and adaptive immunity and are targets for various bacterial and viral adhesins. Two pathogens that colonize t...

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Hauptverfasser: Klaile, Esther (VerfasserIn) , Klassert, Tilman (VerfasserIn) , Scheffrahn, Inka (VerfasserIn) , Müller, Mario (VerfasserIn) , Heinrich, Annina (VerfasserIn) , Heyl, Kerstin Andrea (VerfasserIn) , Dienemann, Hendrik (VerfasserIn) , Grünewald, Christiane (VerfasserIn) , Bals, Robert (VerfasserIn) , Singer, Bernhard Bonaventura (VerfasserIn) , Slevogt, Hortense (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 14 August 2013
In: Respiratory research
Year: 2013, Jahrgang: 14, Pages: 1-17
ISSN:1465-993X
DOI:10.1186/1465-9921-14-85
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1465-9921-14-85
Volltext
Verfasserangaben:Esther Klaile, Tilman E Klassert, Inka Scheffrahn, Mario M Müller, Annina Heinrich, Kerstin A Heyl, Hendrik Dienemann, Christiane Grünewald, Robert Bals, Bernhard B Singer and Hortense Slevogt
Beschreibung
Zusammenfassung:The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung. They play a role in innate and adaptive immunity and are targets for various bacterial and viral adhesins. Two pathogens that colonize the normally sterile lower respiratory tract in patients with chronic obstructive pulmonary disease (COPD) are non-typable Haemophilus influenzae (NTHI) and Moraxella catarrhalis. Both pathogens bind to CEACAMs and elicit a variety of cellular reactions, including bacterial internalization, cell adhesion and apoptosis.
Beschreibung:Gesehen am 22.06.2022
Beschreibung:Online Resource
ISSN:1465-993X
DOI:10.1186/1465-9921-14-85

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