SUMOylation in trypanosoma brucei
Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evi...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
8 October 2013
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| In: |
PeerJ
Year: 2013, Volume: 1, Pages: 1-12 |
| ISSN: | 2167-8359 |
| DOI: | 10.7717/peerj.180 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7717/peerj.180 Verlag, lizenzpflichtig, Volltext: https://peerj.com/articles/180 
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| Author Notes: | Cornelia Andrea Klein, Dorothea Droll and Christine Clayton |
| Summary: | Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evidence that trypanosome homologues of the SUMO conjugating enzyme Ubc9 (Tb927.2.2460) and the SUMO-specific protease SENP (Tb927.9.2220) are involved in SUMOylation and SUMO removal, respectively. |
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| Item Description: | Gesehen am 09.06.2022 |
| Physical Description: | Online Resource |
| ISSN: | 2167-8359 |
| DOI: | 10.7717/peerj.180 |