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Residual γH2AX foci predict local tumour control after radiotherapy

Purpose - Evaluation of micromilieu-dependent quantified γH2AX foci as a potential predictive biomarker in well-oxygenated tumour areas in 9 HNSCC xenograft models in vivo. - Materials & methods - GammaH2AX foci were quantified in perfused tumour areas 30min (initial γH2AX foci) and 24h (residua...

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Hauptverfasser: Koch, Ulrike (VerfasserIn) , Höhne, Katharina (VerfasserIn) , Neubeck, Cläre von (VerfasserIn) , Thames, Howard D. (VerfasserIn) , Yaromina, Ala (VerfasserIn) , Dahm-Daphi, Jochen (VerfasserIn) , Baumann, Michael (VerfasserIn) , Krause, Mechthild (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 25 July 2013
In: Radiotherapy and oncology
Year: 2013, Jahrgang: 108, Heft: 3, Pages: 434-439
ISSN:1879-0887
DOI:10.1016/j.radonc.2013.06.022
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2013.06.022
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814013003010
Volltext
Verfasserangaben:Ulrike Koch, Katharina Höhne, Cläre von Neubeck, Howard D. Thames, Ala Yaromina, Jochen Dahm-Daphi, Michael Baumann, Mechthild Krause
Beschreibung
Zusammenfassung:Purpose - Evaluation of micromilieu-dependent quantified γH2AX foci as a potential predictive biomarker in well-oxygenated tumour areas in 9 HNSCC xenograft models in vivo. - Materials & methods - GammaH2AX foci were quantified in perfused tumour areas 30min (initial γH2AX foci) and 24h (residual γH2AX foci) after exposure to a single dose of 4Gy. The initial and residual normalised γH2AX foci were correlated with TCD50 after single dose irradiation under clamped blood flow (SDclamp) or a fractionated irradiation setting under ambient blood flow (fx). - Results - A significant negative correlation between initial and residual normalised γH2AX foci and TCD50 SDclamp and TCD50 fx for 9 HNSCC tumour xenograft models in vivo was found. Residual normalised γH2AX foci showed higher intertumoural variability and their correlation with TCD50 was more robust. - Conclusions - For the first time a significant negative correlation between γH2AX foci and local tumour control after irradiation has been demonstrated. Our results underline the potential of residual γH2AX foci as a predictive biomarker for local tumour control after radiotherapy.
Beschreibung:Gesehen am 17.12.2021
Beschreibung:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2013.06.022

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