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Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

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Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lamin A (termed...

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Main Authors: Köhler, Florian (Author) , Bormann, Felix (Author) , Raddatz, Günter (Author) , Gutekunst, Julian (Author) , Corless, Samuel (Author) , Musch, Tanja (Author) , Lonsdorf, Anke Susanne (Author) , Erhardt, Sylvia (Author) , Lyko, Frank (Author) , Rodríguez Paredes, Manuel (Author)
Format: Article (Journal)
Language:English
Published: 25 May 2020
In: Genome medicine
Year: 2020, Volume: 12, Pages: 1-16
ISSN:1756-994X
DOI:10.1186/s13073-020-00749-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13073-020-00749-y
Verlag, lizenzpflichtig, Volltext: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00749-y
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Author Notes:Florian Köhler, Felix Bormann, Günter Raddatz, Julian Gutekunst, Samuel Corless, Tanja Musch, Anke S. Lonsdorf, Sylvia Erhardt, Frank Lyko and Manuel Rodríguez-Paredes
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Summary:Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lamin A (termed progerin) and have previously been shown to exhibit prominent histone modification changes.
Item Description:Gesehen am 23.03.2021
Physical Description:Online Resource
ISSN:1756-994X
DOI:10.1186/s13073-020-00749-y

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