Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lamin A (termed...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
25 May 2020
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| In: |
Genome medicine
Year: 2020, Jahrgang: 12, Pages: 1-16 |
| ISSN: | 1756-994X |
| DOI: | 10.1186/s13073-020-00749-y |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13073-020-00749-y Verlag, lizenzpflichtig, Volltext: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00749-y 
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| Verfasserangaben: | Florian Köhler, Felix Bormann, Günter Raddatz, Julian Gutekunst, Samuel Corless, Tanja Musch, Anke S. Lonsdorf, Sylvia Erhardt, Frank Lyko and Manuel Rodríguez-Paredes |
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| 520 | |a Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lamin A (termed progerin) and have previously been shown to exhibit prominent histone modification changes. | ||
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