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TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells

Imiquimod and resiquimod represent Toll-like receptor (TLR) 7 and 8 agonists, which emerged as attractive candidates for tumor therapy. To elucidate immune cells, which mainly contribute to TLR7/8-mediated antitumoral activity, we investigated the impact of imiquimod and resiquimod on native human 6...

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Main Authors: Jähnisch, Hanka (Author) , Wehner, Rebekka (Author) , Tunger, Antje (Author) , Kunze, Anja (Author) , Oehrl, Stephanie (Author) , Schäkel, Knut (Author) , Rohayem, Jacques (Author) , Bornhäuser, Martin (Author) , Tonn, Torsten (Author) , Bachmann, Michael (Author) , Schmitz, Marc (Author)
Format: Article (Journal)
Language:English
Published: 9 February 2013
In: Cancer letters
Year: 2013, Volume: 335, Issue: 1, Pages: 119-127
ISSN:1872-7980
DOI:10.1016/j.canlet.2013.02.003
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.canlet.2013.02.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0304383513001146
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Author Notes:Hanka Jähnisch, Rebekka Wehner, Antje Tunger, Anja Kunze, Stephanie Oehrl, Knut Schäkel, Jacques Rohayem, Martin Bornhäuser, Torsten Tonn, Michael Bachmann, Marc Schmitz
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Summary:Imiquimod and resiquimod represent Toll-like receptor (TLR) 7 and 8 agonists, which emerged as attractive candidates for tumor therapy. To elucidate immune cells, which mainly contribute to TLR7/8-mediated antitumoral activity, we investigated the impact of imiquimod and resiquimod on native human 6-sulfo LacNAc (slan) dendritic cells (DCs). We found that both TLR7/8 agonists significantly improve the release of various proinflammatory cytokines by slanDCs and promote their tumor-directed cytotoxic activity. Furthermore, resiquimod efficiently augmented the ability of slanDCs to stimulate T cells and natural killer cells. These results indicate that imiquimod and resiquimod trigger various immunostimulatory properties of slanDCs, which may contribute to their antitumor effects.
Item Description:Gesehen am 24.03.2021
Physical Description:Online Resource
ISSN:1872-7980
DOI:10.1016/j.canlet.2013.02.003

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