TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells
Imiquimod and resiquimod represent Toll-like receptor (TLR) 7 and 8 agonists, which emerged as attractive candidates for tumor therapy. To elucidate immune cells, which mainly contribute to TLR7/8-mediated antitumoral activity, we investigated the impact of imiquimod and resiquimod on native human 6...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
9 February 2013
|
| In: |
Cancer letters
Year: 2013, Volume: 335, Issue: 1, Pages: 119-127 |
| ISSN: | 1872-7980 |
| DOI: | 10.1016/j.canlet.2013.02.003 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.canlet.2013.02.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0304383513001146 |
| Author Notes: | Hanka Jähnisch, Rebekka Wehner, Antje Tunger, Anja Kunze, Stephanie Oehrl, Knut Schäkel, Jacques Rohayem, Martin Bornhäuser, Torsten Tonn, Michael Bachmann, Marc Schmitz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1752330625 | ||
| 003 | DE-627 | ||
| 005 | 20230125155021.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210324s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.canlet.2013.02.003 |2 doi | |
| 035 | |a (DE-627)1752330625 | ||
| 035 | |a (DE-599)KXP1752330625 | ||
| 035 | |a (OCoLC)1341401119 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Jähnisch, Hanka |d 1986- |e VerfasserIn |0 (DE-588)1016140908 |0 (DE-627)705483118 |0 (DE-576)348774818 |4 aut | |
| 245 | 1 | 0 | |a TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells |c Hanka Jähnisch, Rebekka Wehner, Antje Tunger, Anja Kunze, Stephanie Oehrl, Knut Schäkel, Jacques Rohayem, Martin Bornhäuser, Torsten Tonn, Michael Bachmann, Marc Schmitz |
| 264 | 1 | |c 9 February 2013 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.03.2021 | ||
| 520 | |a Imiquimod and resiquimod represent Toll-like receptor (TLR) 7 and 8 agonists, which emerged as attractive candidates for tumor therapy. To elucidate immune cells, which mainly contribute to TLR7/8-mediated antitumoral activity, we investigated the impact of imiquimod and resiquimod on native human 6-sulfo LacNAc (slan) dendritic cells (DCs). We found that both TLR7/8 agonists significantly improve the release of various proinflammatory cytokines by slanDCs and promote their tumor-directed cytotoxic activity. Furthermore, resiquimod efficiently augmented the ability of slanDCs to stimulate T cells and natural killer cells. These results indicate that imiquimod and resiquimod trigger various immunostimulatory properties of slanDCs, which may contribute to their antitumor effects. | ||
| 650 | 4 | |a Dendritic cells | |
| 650 | 4 | |a Imiquimod | |
| 650 | 4 | |a Immunotherapy | |
| 650 | 4 | |a Resiquimod | |
| 650 | 4 | |a Tumor immunology | |
| 700 | 1 | |a Wehner, Rebekka |d 1980- |e VerfasserIn |0 (DE-588)1147080658 |0 (DE-627)1005977348 |0 (DE-576)284790362 |4 aut | |
| 700 | 1 | |a Tunger, Antje |d 1987- |e VerfasserIn |0 (DE-588)1128092948 |0 (DE-627)882367978 |0 (DE-576)485676079 |4 aut | |
| 700 | 1 | |a Kunze, Anja |e VerfasserIn |0 (DE-588)1082431729 |0 (DE-627)84748565X |0 (DE-576)455414009 |4 aut | |
| 700 | 1 | |a Oehrl, Stephanie |e VerfasserIn |0 (DE-588)1162983159 |0 (DE-627)1027082181 |0 (DE-576)507734203 |4 aut | |
| 700 | 1 | |a Schäkel, Knut |e VerfasserIn |0 (DE-588)1032757418 |0 (DE-627)739272896 |0 (DE-576)251064476 |4 aut | |
| 700 | 1 | |a Rohayem, Jacques |d 1968- |e VerfasserIn |0 (DE-588)124052444 |0 (DE-627)70652098X |0 (DE-576)293998000 |4 aut | |
| 700 | 1 | |a Bornhäuser, Martin |d 1966- |e VerfasserIn |0 (DE-588)1167559118 |0 (DE-627)1031176071 |0 (DE-576)511198817 |4 aut | |
| 700 | 1 | |a Tonn, Torsten |e VerfasserIn |0 (DE-588)1279131012 |0 (DE-627)1832435849 |4 aut | |
| 700 | 1 | |a Bachmann, Michael |d 1956- |e VerfasserIn |0 (DE-588)1047869977 |0 (DE-627)779362098 |0 (DE-576)401692981 |4 aut | |
| 700 | 1 | |a Schmitz, Marc |d 1968- |e VerfasserIn |0 (DE-588)115796622 |0 (DE-627)077478932 |0 (DE-576)18742523X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer letters |d Amsterdam [u.a.] : Elsevier Science, 1975 |g 335(2013), 1, Seite 119-127 |h Online-Ressource |w (DE-627)320434796 |w (DE-600)2004212-7 |w (DE-576)261677926 |x 1872-7980 |7 nnas |a TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells |
| 773 | 1 | 8 | |g volume:335 |g year:2013 |g number:1 |g pages:119-127 |g extent:9 |a TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.canlet.2013.02.003 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0304383513001146 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210324 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1032757418 |a Schäkel, Knut |m 1032757418:Schäkel, Knut |d 910000 |d 911300 |e 910000PS1032757418 |e 911300PS1032757418 |k 0/910000/ |k 1/910000/911300/ |p 6 | ||
| 998 | |g 1162983159 |a Oehrl, Stephanie |m 1162983159:Oehrl, Stephanie |d 910000 |d 911300 |e 910000PO1162983159 |e 911300PO1162983159 |k 0/910000/ |k 1/910000/911300/ |p 5 | ||
| 998 | |g 1082431729 |a Kunze, Anja |m 1082431729:Kunze, Anja |d 910000 |d 950000 |d 950950 |e 910000PK1082431729 |e 950000PK1082431729 |e 950950PK1082431729 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 4 | ||
| 999 | |a KXP-PPN1752330625 |e 3893620982 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1752330625"],"doi":["10.1016/j.canlet.2013.02.003"]},"title":[{"title_sort":"TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells","title":"TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells"}],"name":{"displayForm":["Hanka Jähnisch, Rebekka Wehner, Antje Tunger, Anja Kunze, Stephanie Oehrl, Knut Schäkel, Jacques Rohayem, Martin Bornhäuser, Torsten Tonn, Michael Bachmann, Marc Schmitz"]},"physDesc":[{"extent":"9 S."}],"language":["eng"],"note":["Gesehen am 24.03.2021"],"relHost":[{"recId":"320434796","part":{"pages":"119-127","volume":"335","issue":"1","text":"335(2013), 1, Seite 119-127","extent":"9","year":"2013"},"origin":[{"publisher":"Elsevier Science","dateIssuedDisp":"1975-","publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1975"}],"title":[{"subtitle":"an international journal providing a forum for original and pertinent contributions in cancer research","title_sort":"Cancer letters","title":"Cancer letters"}],"id":{"eki":["320434796"],"issn":["1872-7980"],"zdb":["2004212-7"]},"disp":"TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cellsCancer letters","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 22.01.2020"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.1975 -"]}],"recId":"1752330625","person":[{"role":"aut","family":"Jähnisch","display":"Jähnisch, Hanka","given":"Hanka"},{"given":"Rebekka","display":"Wehner, Rebekka","role":"aut","family":"Wehner"},{"family":"Tunger","role":"aut","given":"Antje","display":"Tunger, Antje"},{"display":"Kunze, Anja","given":"Anja","family":"Kunze","role":"aut"},{"role":"aut","family":"Oehrl","given":"Stephanie","display":"Oehrl, Stephanie"},{"family":"Schäkel","role":"aut","display":"Schäkel, Knut","given":"Knut"},{"display":"Rohayem, Jacques","given":"Jacques","family":"Rohayem","role":"aut"},{"display":"Bornhäuser, Martin","given":"Martin","family":"Bornhäuser","role":"aut"},{"display":"Tonn, Torsten","given":"Torsten","role":"aut","family":"Tonn"},{"family":"Bachmann","role":"aut","given":"Michael","display":"Bachmann, Michael"},{"family":"Schmitz","role":"aut","given":"Marc","display":"Schmitz, Marc"}],"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"9 February 2013"}]} | ||
| SRT | |a JAEHNISCHHTLR78AGONI9201 | ||