TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells
Imiquimod and resiquimod represent Toll-like receptor (TLR) 7 and 8 agonists, which emerged as attractive candidates for tumor therapy. To elucidate immune cells, which mainly contribute to TLR7/8-mediated antitumoral activity, we investigated the impact of imiquimod and resiquimod on native human 6...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
9 February 2013
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| In: |
Cancer letters
Year: 2013, Jahrgang: 335, Heft: 1, Pages: 119-127 |
| ISSN: | 1872-7980 |
| DOI: | 10.1016/j.canlet.2013.02.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.canlet.2013.02.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0304383513001146 
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| Verfasserangaben: | Hanka Jähnisch, Rebekka Wehner, Antje Tunger, Anja Kunze, Stephanie Oehrl, Knut Schäkel, Jacques Rohayem, Martin Bornhäuser, Torsten Tonn, Michael Bachmann, Marc Schmitz |
MARC
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| 245 | 1 | 0 | |a TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells |c Hanka Jähnisch, Rebekka Wehner, Antje Tunger, Anja Kunze, Stephanie Oehrl, Knut Schäkel, Jacques Rohayem, Martin Bornhäuser, Torsten Tonn, Michael Bachmann, Marc Schmitz |
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| 520 | |a Imiquimod and resiquimod represent Toll-like receptor (TLR) 7 and 8 agonists, which emerged as attractive candidates for tumor therapy. To elucidate immune cells, which mainly contribute to TLR7/8-mediated antitumoral activity, we investigated the impact of imiquimod and resiquimod on native human 6-sulfo LacNAc (slan) dendritic cells (DCs). We found that both TLR7/8 agonists significantly improve the release of various proinflammatory cytokines by slanDCs and promote their tumor-directed cytotoxic activity. Furthermore, resiquimod efficiently augmented the ability of slanDCs to stimulate T cells and natural killer cells. These results indicate that imiquimod and resiquimod trigger various immunostimulatory properties of slanDCs, which may contribute to their antitumor effects. | ||
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| 650 | 4 | |a Immunotherapy | |
| 650 | 4 | |a Resiquimod | |
| 650 | 4 | |a Tumor immunology | |
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