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Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma

An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, whereas binding to TRAIL-R3 and TRAIL-R4 might promote...

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Main Authors: Koschny, Ronald (Author) , Brost, Sylvia (Author) , Hinz, Ulf (Author) , Sykora, Jaromir (Author) , Batke, Emanuela M. (Author) , Singer, Stephan (Author) , Breuhahn, Kai (Author) , Stremmel, Wolfgang (Author) , Walczak, Henning (Author) , Schemmer, Peter (Author) , Schirmacher, Peter (Author) , Ganten, Tom M. (Author)
Format: Article (Journal)
Language:English
Published: 9 November 2013
In: BMC cancer
Year: 2013, Volume: 13, Pages: 1-11
ISSN:1471-2407
DOI:10.1186/1471-2407-13-532
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2407-13-532
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Author Notes:Ronald Koschny, Sylvia Brost, Ulf Hinz, Jaromir Sykora, Emanuela M. Batke, Stephan Singer, Kai Breuhahn, Wolfgang Stremmel, Henning Walczak, Peter Schemmer, Peter Schirmacher and Tom M. Ganten
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Summary:An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, whereas binding to TRAIL-R3 and TRAIL-R4 might promote cell survival and proliferation. The anti-tumor activity of TRAIL-R1 and TRAIL-R2 agonists is currently investigated in clinical trials. To gain further insight into the regulation of apoptosis in hepatocellular carcinoma (HCC), we investigated the TRAIL pathway and the regulators of apoptosis caspase-8, Bcl-xL and Mcl-1 in patients with HCC regarding patient survival.
Item Description:Gesehen am 04.11.2021
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-13-532

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