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Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE)

The aim of the present study was a detailed analysis of the regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE) by means of functional magnetic resonance imaging (MRI). A group of 26 patients with SAE and a group of 16 age-matched healthy...

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Main Authors: Gückel, Friedemann (Author) , Brix, Gunnar (Author) , Hennerici, Michael G. (Author) , Lucht, Robert (Author) , Ueltzhöffer, Christine (Author) , Neff, Wolfgang (Author)
Format: Article (Journal)
Language:English
Published: 6 March 2007
In: European radiology
Year: 2007, Volume: 17, Issue: 10, Pages: 2483-2490
ISSN:1432-1084
DOI:10.1007/s00330-007-0617-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00330-007-0617-y
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Author Notes:Friedemann J. Gückel, Gunnar Brix, Michael Hennerici, Robert Lucht, Christine Ueltzhöffer, Wolfgang Neff
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Summary:The aim of the present study was a detailed analysis of the regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE) by means of functional magnetic resonance imaging (MRI). A group of 26 patients with SAE and a group of 16 age-matched healthy volunteers were examined. Using a well-established dynamic susceptibility contrast-enhanced MRI method, the regional cerebral blood flow (rCBF) and blood volume (rCBV) were quantified for each subject in 12 different regions in the brain parenchyma. As compared to healthy volunteers, patients with SAE showed significantly reduced rCBF and rCBV values in white matter regions and in the occipital cortex. Regions containing predominantly grey matter show almost normal rCBF and rCBV values. In conclusion, quantitative analysis of rCBF and rCBV values demonstrates clearly that SAE is a disease that is associated with a reduced microcirculation predominantly in white matter.
Item Description:Gesehen am 26.03.2021
Physical Description:Online Resource
ISSN:1432-1084
DOI:10.1007/s00330-007-0617-y

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