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Organisation of the murine 5-HT3 receptor gene and assignment tohuman chromosome 11

We have isolated the murine gene encoding the 5-HT3 receptor (5-HT3R), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5-HT3R gene revealed its organisation in 9 exons distributed over approxi...

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Bibliographic Details
Main Authors: Uetz, Peter (Author) , Abdelatty, Fawzy (Author) , Villarroel, Alfredo (Author) , Rappold, Gudrun (Author) , Weiß, Birgit (Author) , Koenen, Michael (Author)
Format: Article (Journal)
Language:English
Published: February 21, 1994
In: FEBS letters
Year: 1994, Volume: 339, Issue: 3, Pages: 302-306
ISSN:1873-3468
DOI:https://doi.org/10.1016/0014-5793(94)80435-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1016/0014-5793(94)80435-4
Verlag, lizenzpflichtig, Volltext: https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2894%2980435-4
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Author Notes:Peter Uetz, Fawzy Abdelatty, Alfredo Villarroel, Gudrun Rappold, Birgit Weiss, Michael Koenen
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Summary:We have isolated the murine gene encoding the 5-HT3 receptor (5-HT3R), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5-HT3R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use ofexon 9 splice acceptor sites generated two 5-HT3R variants. The 5-HT3R gene, whose structure is closely related to neuronal and muscle AChRα genes, as demonstrated by four common splice junctions, was localised on human chromosome 11.
Item Description:Gesehen am 31.03.2021
Physical Description:Online Resource
ISSN:1873-3468
DOI:https://doi.org/10.1016/0014-5793(94)80435-4

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