Organisation of the murine 5-HT3 receptor gene and assignment tohuman chromosome 11
We have isolated the murine gene encoding the 5-HT3 receptor (5-HT3R), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5-HT3R gene revealed its organisation in 9 exons distributed over approxi...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 21, 1994
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| In: |
FEBS letters
Year: 1994, Jahrgang: 339, Heft: 3, Pages: 302-306 |
| ISSN: | 1873-3468 |
| DOI: | https://doi.org/10.1016/0014-5793(94)80435-4 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1016/0014-5793(94)80435-4 Verlag, lizenzpflichtig, Volltext: https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2894%2980435-4 
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| Verfasserangaben: | Peter Uetz, Fawzy Abdelatty, Alfredo Villarroel, Gudrun Rappold, Birgit Weiss, Michael Koenen |
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| 245 | 1 | 0 | |a Organisation of the murine 5-HT3 receptor gene and assignment tohuman chromosome 11 |c Peter Uetz, Fawzy Abdelatty, Alfredo Villarroel, Gudrun Rappold, Birgit Weiss, Michael Koenen |
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| 520 | |a We have isolated the murine gene encoding the 5-HT3 receptor (5-HT3R), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5-HT3R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use ofexon 9 splice acceptor sites generated two 5-HT3R variants. The 5-HT3R gene, whose structure is closely related to neuronal and muscle AChRα genes, as demonstrated by four common splice junctions, was localised on human chromosome 11. | ||
| 650 | 4 | |a Alternative splicing | |
| 650 | 4 | |a Exon alignment | |
| 650 | 4 | |a Gene structure | |
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