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Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin

Colorectal familial adenomatous polyposis (FAP) adenomas exhibit a uniform pathogenetic basis caused by a germline mutation in the adenomatous polyposis gene (APC), but the molecular changes leading to their development are incompletely understood. However, dysregulated apoptosis is known to substan...

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Bibliographische Detailangaben
Hauptverfasser: Roser, Christoph (VerfasserIn) , Tóth, Csaba (VerfasserIn) , Renner, Marcus (VerfasserIn) , Herpel, Esther (VerfasserIn) , Schirmacher, Peter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 12 February 2021
In: Cell communication and signaling
Year: 2021, Jahrgang: 19, Pages: 1-11
ISSN:1478-811X
DOI:10.1186/s12964-020-00702-x
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12964-020-00702-x
Volltext
Verfasserangaben:Christoph Roser, Csaba Tóth, Marcus Renner, Esther Herpel and Peter Schirmacher
Beschreibung
Zusammenfassung:Colorectal familial adenomatous polyposis (FAP) adenomas exhibit a uniform pathogenetic basis caused by a germline mutation in the adenomatous polyposis gene (APC), but the molecular changes leading to their development are incompletely understood. However, dysregulated apoptosis is known to substantially affect the development of colonic adenomas. One of the key regulatory proteins involved in apoptosis is apoptosis repressor with caspase recruitment domain (ARC).
Beschreibung:Gesehen am 01.04.2021
Beschreibung:Online Resource
ISSN:1478-811X
DOI:10.1186/s12964-020-00702-x

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