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MR-guided radiotherapy: the perfect partner for immunotherapy?

During the last years, preclinical and clinical studies have emerged supporting the rationale to integrate radiotherapy and immunotherapy. Radiotherapy may enhance the effects of immunotherapy by improving tumor antigen release, antigen presentation and T-cell infiltration. Recently, magnetic resona...

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Main Authors: Hörner-Rieber, Juliane (Author) , Klüter, Sebastian (Author) , Debus, Jürgen (Author) , Adema, Gosse (Author) , Ansems, Marleen (Author) , Verheij, Marcel (Author)
Format: Article (Journal)
Language:English
Published: 02 February 2021
In: Frontiers in oncology
Year: 2021, Volume: 10, Pages: 1-8
ISSN:2234-943X
DOI:10.3389/fonc.2020.615697
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fonc.2020.615697
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fonc.2020.615697/full
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Author Notes:Juliane Hörner-Rieber, Sebastian Klüter, Jürgen Debus, Gosse Adema, Marleen Ansems and Marcel Verheij
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Summary:During the last years, preclinical and clinical studies have emerged supporting the rationale to integrate radiotherapy and immunotherapy. Radiotherapy may enhance the effects of immunotherapy by improving tumor antigen release, antigen presentation and T-cell infiltration. Recently, magnetic resonance guided radiotherapy (MRgRT) has become clinically available. Compared to conventional radiotherapy techniques, MRgRT firstly allows for daily on-table treatment adaptation, which enables both dose escalation for increasing tumor response and superior sparing of radiosensitive organs-at-risk for reducing toxicity. The current review focuses on the potential of combining MR-guided adaptive radiotherapy with immunotherapy by providing an overview on the current status of MRgRT, latest developments in preclinical and clinical radio-immunotherapy and the unique opportunities and challenges for MR-guided radio-immunotherapy. MRgRT might especially assist in answering open questions in radio-immunotherapy regarding optimal radiation dose, fractionation, timing of immunotherapy, appropriate irradiation volumes and response prediction.
Item Description:Gesehen am 06.04.2021
Physical Description:Online Resource
ISSN:2234-943X
DOI:10.3389/fonc.2020.615697

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