CGP 55845A blocks baclofen, γ-aminobutyric acid and inhibitory postsynaptic potassium currents in guinea pig CA3 neurons
Single electrode voltage-clamp recording from CA3 neurons in guinea pig hippocampal slices was applied to study effects of a new GABAB antagonist, CGP 55845A, on (−)baclofen (IBac)- or γ-aminobutyric acid (IGABA)-induced potassium (K)-currents and on inhibitory postsynaptic K-currents (K-IPSCs) reco...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1993
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| In: |
Neuroscience letters
Year: 1993, Volume: 154, Issue: 1, Pages: 31-34 |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/0304-3940(93)90164-G |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/0304-3940(93)90164-G Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/030439409390164G 
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| Author Notes: | W. Jarolimek, J. Demmelhuber, M. Bijak and U. Misgeld |
| Summary: | Single electrode voltage-clamp recording from CA3 neurons in guinea pig hippocampal slices was applied to study effects of a new GABAB antagonist, CGP 55845A, on (−)baclofen (IBac)- or γ-aminobutyric acid (IGABA)-induced potassium (K)-currents and on inhibitory postsynaptic K-currents (K-IPSCs) recorded in the presence of blockers for fast synaptic transmission. K-IPSCs were induced by bath application of 4-aminopyridine (4-AP). CGP 55845A, in 10−8 to 10−7 M concentrations, blocked all these K-currents and was more potent than all GABAB antagonists known to date. However, onset of the CGP 55845A effect and recovery were slow. We conclude that a potent and selective GABAB antagonist is now available to study the physiological role of GABAB receptors in the mammalian brain. |
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| Item Description: | Online 24 March 2003 Elektronische Reproduktion der Druck-Ausgabe Gesehen am 08.04.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/0304-3940(93)90164-G |