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DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer

Lung cancer is the leading cause of cancer-related death in most western countries in both, males and females, accounting for roughly 20-25% of all cancer deaths. For choosing the most appropriate therapy regimen a definite diagnosis is a prerequisite. However, histological characterization of bronc...

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Main Authors: Goldmann, Torsten (Author) , Schmitt, Bernhard (Author) , Müller, Julia (Author) , Kröger, Maren (Author) , Scheufele, Swetlana (Author) , Marwitz, Sebastian (Author) , Nitschkowski, Dörte (Author) , Schneider, Marc (Author) , Meister, Michael (Author) , Muley, Thomas (Author) , Thomas, Michael (Author) , Kugler, Christian (Author) , Rabe, Klaus F. (Author) , Siebert, Reiner (Author) , Reck, Martin (Author) , Ammerpohl, Ole (Author)
Format: Article (Journal)
Language:English
Published: 17 February 2021
In: Clinical epigenetics
Year: 2021, Volume: 13, Pages: 1-11
ISSN:1868-7083
DOI:10.1186/s13148-021-01024-6
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13148-021-01024-6
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Author Notes:Torsten Goldmann, Bernhard Schmitt, Julia Müller, Maren Kröger, Swetlana Scheufele, Sebastian Marwitz, Dörte Nitschkowski, Marc A. Schneider, Michael Meister, Thomas Muley, Michael Thomas, Christian Kugler, Klaus F. Rabe, Reiner Siebert, Martin Reck and Ole Ammerpohl
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Summary:Lung cancer is the leading cause of cancer-related death in most western countries in both, males and females, accounting for roughly 20-25% of all cancer deaths. For choosing the most appropriate therapy regimen a definite diagnosis is a prerequisite. However, histological characterization of bronchoscopic biopsies particularly with low tumor cell content is often challenging. Therefore, this study aims at (a) determining the value of DNA methylation analysis applied to specimens obtained by bronchoscopic biopsy for the diagnosis of lung cancer and (b) at comparing aberrantly CpG loci identified in bronchoscopic biopsy with those identified by analyzing surgical specimens.
Item Description:Gesehen am 08.04.2021
Physical Description:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-021-01024-6

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