DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer
Lung cancer is the leading cause of cancer-related death in most western countries in both, males and females, accounting for roughly 20-25% of all cancer deaths. For choosing the most appropriate therapy regimen a definite diagnosis is a prerequisite. However, histological characterization of bronc...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 February 2021
|
| In: |
Clinical epigenetics
Year: 2021, Volume: 13, Pages: 1-11 |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-021-01024-6 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13148-021-01024-6 |
| Author Notes: | Torsten Goldmann, Bernhard Schmitt, Julia Müller, Maren Kröger, Swetlana Scheufele, Sebastian Marwitz, Dörte Nitschkowski, Marc A. Schneider, Michael Meister, Thomas Muley, Michael Thomas, Christian Kugler, Klaus F. Rabe, Reiner Siebert, Martin Reck and Ole Ammerpohl |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1753353238 | ||
| 003 | DE-627 | ||
| 005 | 20220819160234.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210408s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13148-021-01024-6 |2 doi | |
| 035 | |a (DE-627)1753353238 | ||
| 035 | |a (DE-599)KXP1753353238 | ||
| 035 | |a (OCoLC)1341403639 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Goldmann, Torsten |d 1965- |e VerfasserIn |0 (DE-588)113725248 |0 (DE-627)510150543 |0 (DE-576)289772516 |4 aut | |
| 245 | 1 | 0 | |a DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer |c Torsten Goldmann, Bernhard Schmitt, Julia Müller, Maren Kröger, Swetlana Scheufele, Sebastian Marwitz, Dörte Nitschkowski, Marc A. Schneider, Michael Meister, Thomas Muley, Michael Thomas, Christian Kugler, Klaus F. Rabe, Reiner Siebert, Martin Reck and Ole Ammerpohl |
| 264 | 1 | |c 17 February 2021 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.04.2021 | ||
| 520 | |a Lung cancer is the leading cause of cancer-related death in most western countries in both, males and females, accounting for roughly 20-25% of all cancer deaths. For choosing the most appropriate therapy regimen a definite diagnosis is a prerequisite. However, histological characterization of bronchoscopic biopsies particularly with low tumor cell content is often challenging. Therefore, this study aims at (a) determining the value of DNA methylation analysis applied to specimens obtained by bronchoscopic biopsy for the diagnosis of lung cancer and (b) at comparing aberrantly CpG loci identified in bronchoscopic biopsy with those identified by analyzing surgical specimens. | ||
| 650 | 4 | |a DNA methylation | |
| 650 | 4 | |a Lung cancer | |
| 650 | 4 | |a Paired biopsies | |
| 700 | 1 | |a Schmitt, Bernhard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Müller, Julia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kröger, Maren |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scheufele, Swetlana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marwitz, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nitschkowski, Dörte |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schneider, Marc |d 1982- |e VerfasserIn |0 (DE-588)140634401 |0 (DE-627)620239948 |0 (DE-576)319208095 |4 aut | |
| 700 | 1 | |a Meister, Michael |e VerfasserIn |0 (DE-588)1078792046 |0 (DE-627)839461402 |0 (DE-576)451890108 |4 aut | |
| 700 | 1 | |a Muley, Thomas |e VerfasserIn |0 (DE-588)1056885432 |0 (DE-627)794179169 |0 (DE-576)16759284X |4 aut | |
| 700 | 1 | |a Thomas, Michael |e VerfasserIn |0 (DE-588)1054438781 |0 (DE-627)79152213X |0 (DE-576)41027089X |4 aut | |
| 700 | 1 | |a Kugler, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rabe, Klaus F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Siebert, Reiner |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reck, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ammerpohl, Ole |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical epigenetics |d [Erscheinungsort nicht ermittelbar] : BioMed Central, 2010 |g 13(2021), Artikel-ID 38, Seite 1-11 |h Online-Ressource |w (DE-627)626459028 |w (DE-600)2553921-8 |w (DE-576)325002916 |x 1868-7083 |7 nnas |a DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer |
| 773 | 1 | 8 | |g volume:13 |g year:2021 |g elocationid:38 |g pages:1-11 |g extent:11 |a DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s13148-021-01024-6 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210408 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1054438781 |a Thomas, Michael |m 1054438781:Thomas, Michael |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PT1054438781 |e 950000PT1054438781 |e 950900PT1054438781 |e 50000PT1054438781 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 11 | ||
| 998 | |g 1056885432 |a Muley, Thomas |m 1056885432:Muley, Thomas |d 910000 |d 950000 |d 950900 |e 910000PM1056885432 |e 950000PM1056885432 |e 950900PM1056885432 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 10 | ||
| 998 | |g 1078792046 |a Meister, Michael |m 1078792046:Meister, Michael |d 910000 |d 950000 |d 950900 |e 910000PM1078792046 |e 950000PM1078792046 |e 950900PM1078792046 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 9 | ||
| 998 | |g 140634401 |a Schneider, Marc |m 140634401:Schneider, Marc |d 50000 |e 50000PS140634401 |k 0/50000/ |p 8 | ||
| 999 | |a KXP-PPN1753353238 |e 3903417580 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1753353238","relHost":[{"disp":"DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancerClinical epigenetics","physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Clinical epigenetics","title_sort":"Clinical epigenetics"}],"part":{"volume":"13","extent":"11","text":"13(2021), Artikel-ID 38, Seite 1-11","year":"2021","pages":"1-11"},"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"eki":["626459028"],"zdb":["2553921-8"],"issn":["1868-7083"]},"language":["eng"],"recId":"626459028","pubHistory":["1.2010 -"],"note":["Gesehen am 27.05.2020"],"origin":[{"publisherPlace":"[Erscheinungsort nicht ermittelbar] ; Berlin ; Heidelberg [u.a.]","dateIssuedDisp":"2010-","publisher":"BioMed Central ; Springer","dateIssuedKey":"2010"}]}],"origin":[{"dateIssuedDisp":"17 February 2021","dateIssuedKey":"2021"}],"note":["Gesehen am 08.04.2021"],"title":[{"title":"DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer","title_sort":"DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer"}],"person":[{"role":"aut","given":"Torsten","display":"Goldmann, Torsten","family":"Goldmann"},{"role":"aut","given":"Bernhard","display":"Schmitt, Bernhard","family":"Schmitt"},{"family":"Müller","display":"Müller, Julia","given":"Julia","role":"aut"},{"family":"Kröger","display":"Kröger, Maren","given":"Maren","role":"aut"},{"family":"Scheufele","display":"Scheufele, Swetlana","given":"Swetlana","role":"aut"},{"family":"Marwitz","role":"aut","given":"Sebastian","display":"Marwitz, Sebastian"},{"family":"Nitschkowski","role":"aut","given":"Dörte","display":"Nitschkowski, Dörte"},{"family":"Schneider","display":"Schneider, Marc","given":"Marc","role":"aut"},{"role":"aut","display":"Meister, Michael","given":"Michael","family":"Meister"},{"display":"Muley, Thomas","given":"Thomas","role":"aut","family":"Muley"},{"role":"aut","given":"Michael","display":"Thomas, Michael","family":"Thomas"},{"family":"Kugler","given":"Christian","display":"Kugler, Christian","role":"aut"},{"display":"Rabe, Klaus F.","given":"Klaus F.","role":"aut","family":"Rabe"},{"role":"aut","given":"Reiner","display":"Siebert, Reiner","family":"Siebert"},{"display":"Reck, Martin","given":"Martin","role":"aut","family":"Reck"},{"family":"Ammerpohl","role":"aut","display":"Ammerpohl, Ole","given":"Ole"}],"physDesc":[{"extent":"11 S."}],"id":{"eki":["1753353238"],"doi":["10.1186/s13148-021-01024-6"]},"language":["eng"],"name":{"displayForm":["Torsten Goldmann, Bernhard Schmitt, Julia Müller, Maren Kröger, Swetlana Scheufele, Sebastian Marwitz, Dörte Nitschkowski, Marc A. Schneider, Michael Meister, Thomas Muley, Michael Thomas, Christian Kugler, Klaus F. Rabe, Reiner Siebert, Martin Reck and Ole Ammerpohl"]},"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a GOLDMANNTODNAMETHYLA1720 | ||