Multidirectional walking in hematopoietic stem cell transplant patients
Background - The effect of a peritransplant multidirectional walking intervention to target losses in physical function and quality of life (QOL) has not been investigated. - Purpose - This study examined the effects of a novel multidirectional walking program on physical function and QOL in adult...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2021
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| In: |
Medicine and science in sports and exercise
Year: 2021, Volume: 53, Issue: 2, Pages: 258-266 |
| ISSN: | 1530-0315 |
| DOI: | 10.1249/MSS.0000000000002474 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1249/MSS.0000000000002474 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/acsm-msse/Fulltext/2021/02000/Multidirectional_Walking_in_Hematopoietic_Stem.2.aspx 
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| Author Notes: | Melanie Potiaumpai, Stacy Cutrono, Tamia Medina, Maximillian Koeppel, Denise L. Pereira, William F. Pirl, Kevin A. Jacobs, Moataz Eltoukhy, and Joseph F. Signorile |
| Summary: | Background - The effect of a peritransplant multidirectional walking intervention to target losses in physical function and quality of life (QOL) has not been investigated. - Purpose - This study examined the effects of a novel multidirectional walking program on physical function and QOL in adults receiving a hematopoietic stem cell transplant (HSCT). - Methods - Thirty-five adults receiving an autologous or allogeneic HSCT were randomized to a multidirectional walking (WALK) or usual care (CONT) group. The WALK group received supervised training during hospitalization; the CONT group received usual care. Patients were assessed at admission (t0), 3 to 5 d post-HSCT (t1), and 30 d post-HSCT (t2). Physical function measures included the 6-min walk test (6MWT), the Physical Performance Test, and the Timed Up and Go test. Health-related QOL was collected using the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) questionnaire. - Results - There were no significant between-group changes for physical function or QOL. However, after the intervention (t1 to t2), the WALK group showed significant improvement in aerobic capacity (6MWT, P = 0.01), physical (P < 0.01) and functional well-being (P = 0.04), and overall QOL scores (P < 0.01). The CONT group saw no significant changes in physical function or QOL. Effect sizes showed the WALK group had a larger positive effect on physical function and QOL. Minimal clinically important differences in the 6MWT and FACT-BMT were exceeded in the WALK group. - Conclusion - A multidirectional walking program during the transplant period may be effective at increasing aerobic capacity and QOL for patients receiving HSCT compared with no structured exercise. |
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| Item Description: | Gesehen am 08.04.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1530-0315 |
| DOI: | 10.1249/MSS.0000000000002474 |