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Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. In a prospective multicentric study, we identify IL-3 as an independent prognostic marker for the outcome during SARS-CoV-2 infections. Specifically, low plasma IL-3 levels is associated with increased severit...

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Main Authors: Bénard, Alan (Author) , Jacobsen, Anne (Author) , Brunner, Maximilian (Author) , Krautz, Christian (Author) , Klösch, Bettina (Author) , Swierzy, Izabela (Author) , Naschberger, Elisabeth (Author) , Podolska, Malgorzata J. (Author) , Kouhestani, Dina (Author) , David, Paul (Author) , Birkholz, Torsten (Author) , Castellanos, Ixchel (Author) , Trufa, Denis (Author) , Sirbu, Horia (Author) , Vetter, Marcel (Author) , Kremer, Andreas E. (Author) , Hildner, Kai (Author) , Hecker, Andreas (Author) , Edinger, Fabian (Author) , Tenbusch, Matthias (Author) , Mühl-Zürbes, Petra (Author) , Steinkasserer, Alexander (Author) , Richter, Enrico (Author) , Streeck, Hendrik (Author) , Berger, Marc Moritz (Author) , Brenner, Thorsten (Author) , Weigand, Markus A. (Author) , Swirski, Filip K. (Author) , Schett, Georg (Author) , Grützmann, Robert (Author) , Weber, Georg Ferdinand (Author)
Format: Article (Journal)
Language:English
Published: 18 February 2021
In: Nature Communications
Year: 2021, Volume: 12, Pages: 1-8
ISSN:2041-1723
DOI:10.1038/s41467-021-21310-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-021-21310-4
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-021-21310-4
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Author Notes:Alan Bénard, Anne Jacobsen, Maximilian Brunner, Christian Krautz, Bettina Klösch, Izabela Swierzy, Elisabeth Naschberger, Malgorzata J. Podolska, Dina Kouhestani, Paul David, Torsten Birkholz, Ixchel Castellanos, Denis Trufa, Horia Sirbu, Marcel Vetter, Andreas E. Kremer, Kai Hildner, Andreas Hecker, Fabian Edinger, Matthias Tenbusch, Petra Mühl-Zürbes, Alexander Steinkasserer, Enrico Richter, Hendrik Streeck, Marc M. Berger, Thorsten Brenner, Markus A. Weigand, Filip K. Swirski, Georg Schett, Robert Grützmann & Georg F. Weber
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Summary:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. In a prospective multicentric study, we identify IL-3 as an independent prognostic marker for the outcome during SARS-CoV-2 infections. Specifically, low plasma IL-3 levels is associated with increased severity, viral load, and mortality during SARS-CoV-2 infections. Patients with severe COVID-19 exhibit also reduced circulating plasmacytoid dendritic cells (pDCs) and low plasma IFNα and IFNλ levels when compared to non-severe COVID-19 patients. In a mouse model of pulmonary HSV-1 infection, treatment with recombinant IL-3 reduces viral load and mortality. Mechanistically, IL-3 increases innate antiviral immunity by promoting the recruitment of circulating pDCs into the airways by stimulating CXCL12 secretion from pulmonary CD123+ epithelial cells, both, in mice and in COVID-19 negative patients exhibiting pulmonary diseases. This study identifies IL-3 as a predictive disease marker for SARS-CoV-2 infections and as a potential therapeutic target for pulmunory viral infections.
Item Description:Gesehen am 02.09.2021
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-021-21310-4

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