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Energy metabolites as biomarkers in ischemic and dilated cardiomyopathy

With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and...

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Main Authors: Haas, Jan (Author) , Frese, Karen S. (Author) , Sedaghat-Hamedani, Farbod (Author) , Kayvanpour, Elham (Author) , Tappu, Rewati (Author) , Nietsch, Rouven (Author) , Tugrul, Oguz Firat (Author) , Wisdom, Michael (Author) , Dietrich, Carsten (Author) , Amr, Ali (Author) , Weis, Tanja (Author) , Niederdränk, Torsten (Author) , Murphy, Michael P. (Author) , Krieg, Thomas (Author) , Dörr, Marcus (Author) , Völker, Uwe (Author) , Fielitz, Jens (Author) , Frey, Norbert (Author) , Felix, Stephan B. (Author) , Keller, Andreas (Author) , Katus, Hugo (Author) , Meder, Benjamin (Author)
Format: Article (Journal)
Language:English
Published: 18 February 2021
In: International journal of molecular sciences
Year: 2021, Volume: 22, Issue: 4, Pages: 1-13
ISSN:1422-0067
DOI:10.3390/ijms22041999
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms22041999
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/22/4/1999
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Author Notes:Jan Haas, Karen S. Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Rewati Tappu, Rouven Nietsch, Oguz Firat Tugrul, Michael Wisdom, Carsten Dietrich, Ali Amr, Tanja Weis, Torsten Niederdränk, Michael P. Murphy, Thomas Krieg, Marcus Dörr, Uwe Völker, Jens Fielitz, Norbert Frey, Stephan B. Felix, Andreas Keller, Hugo A. Katus and Benjamin Meder
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Summary:With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from n = 82 patients with Dilated Cardiomyopathy (DCM) and n = 51 controls in the screening stage. We identified several metabolites involved in glycolysis and citric acid cycle to be elevated up to 5.7-fold in DCM (p = 1.7 × 10−6). Interestingly, cardiac mRNA and epigenetic changes of genes encoding rate-limiting enzymes of these pathways could also be found and validated in our second stage of metabolite assessment in n = 52 DCM, n = 39 ischemic HF and n = 57 controls. In conclusion, we identified a new set of metabolomic biomarkers for HF. We were able to identify underlying biological cascades that potentially represent suitable intervention targets.
Item Description:Gesehen am 27.08.2021
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms22041999

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