Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study
We read with great interest the study by Coker et al 1 that provided supportive evidence for the role of oral microbiota in gastric cancer. A few studies also highlighted the possible link with oesophageal cancer.2-4 However, there is a lack of robust epidemiologic data on whether periodontal diseas...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
2021
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| In: |
Gut
Year: 2021, Volume: 70, Issue: 3, Pages: 620-621 |
| ISSN: | 1468-3288 |
| DOI: | 10.1136/gutjnl-2020-321949 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/gutjnl-2020-321949 Verlag, lizenzpflichtig, Volltext: https://gut.bmj.com/content/70/3/620 
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| Author Notes: | Chun-Han Lo, Sohee Kwon, Liang Wang, Georgios Polychronidis, Markus D. Knudsen, Rong Zhong, Yin Cao, Kana Wu, Shuji Ogino, Edward L. Giovannucci, Andrew T. Chan, Mingyang Song |
| Summary: | We read with great interest the study by Coker et al 1 that provided supportive evidence for the role of oral microbiota in gastric cancer. A few studies also highlighted the possible link with oesophageal cancer.2-4 However, there is a lack of robust epidemiologic data on whether periodontal disease and tooth loss, indicators of oral microbial dysbiosis, are associated with these two cancers. - - Here, we prospectively examined the association of history of periodontal disease and tooth loss with the risk of oesophageal and gastric adenocarcinoma in 98 459 women from the Nurses’ Health Study (1992-2014) and 49 685 men from the Health Professionals Follow-up Study (1988-2016). Dental measures, demographics, lifestyle, and diet were assessed using validated follow-up questionnaires. Self-reported cancer diagnosis was confirmed by review of medical records. We used Cox proportional hazards models to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). We also examined the independent association of history of periodontal disease and tooth loss in a joint analysis. - - Over 22-28 years of follow-up, we documented 199 cases of oesophageal adenocarcinoma and 238 cases of gastric adenocarcinoma. History of periodontal disease was associated with a 43% and 52% increased risk of oesophageal adenocarcinoma (multivariable-adjusted HR (aHR) 1.43, 95% CI 1.05 to 1.96) and gastric adenocarcinoma (aHR 1.52, 95% CI 1.13 to 2.04) (table … |
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| Item Description: | Published online first 20 July 2020 Gesehen am 26.08.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1468-3288 |
| DOI: | 10.1136/gutjnl-2020-321949 |